Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRD5A2 | P31213 | 1/20 | 0.40 |
| ▸ | HSP90AB1 | P08238 | 3/20 | 0.38 |
| ▸ | KDM2B | Q8NHM5 | 4/20 | 0.37 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | MGLL | Q99685 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.33 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7117535 | 0.80 | HSD17B1 (0.41) | KDM4EHTTRAB9AMAPTHPGD | |
| SCHEMBL14098262 | 0.78 | RAB9A (0.44) | SRD5A2HSP90AB1CNR2ALDH1A1LMNA | |
| SCHEMBL5112413 | 0.77 | ATM (0.45) | HSP90AB1HTTALDH1A1MAPTHPGD | |
| SCHEMBL14098249 | 0.77 | SRD5A2 (0.40) | SRD5A2KDM2BCNR1CNR2KDM4E | |
| SCHEMBL14098242 | 0.75 | HPGD (0.47) | ALDH1A1RAB9AMAPTHPGDNPC1 | |
| SCHEMBL14098246 | 0.74 | HSD17B3 (0.45) | KDM4EHTTALDH1A1HPGDPDE4B | |
| SCHEMBL14098252 | 0.73 | KDM2B (0.38) | SRD5A2KDM2BCNR1CNR2MGLL | |
| SCHEMBL7112263 | 0.72 | AHR (0.39) | SRD5A2HTTALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL7111884 | 0.72 | MAPKAPK2 (0.35) | HSP90AB1CNR1KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL5107101 | 0.72 | AHR (0.39) | SRD5A2KDM4EALDH1A1SMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7410997-B2 | Tricyclic fused heterocycle compounds, process for preparing the same and use thereof | NIPPON SULSAN KAISHA, LTD. (JP) | 2008-08-12 | — | — | US | disclosed |
| US-7410997-B2 | Tricyclic fused heterocycle compounds, process for preparing the same and use thereof | NIPPON SULSAN KAISHA, LTD. (JP) | 2008-08-12 | — | — | US | disclosed |