SCHEMBL140992

SCHEMBL140992

Cc1ccc(S(=O)(=O)OCC(O)COS(=O)(=O)c2ccc(C)cc2)cc1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
STAT3 P40763 2/20 0.46
ALDH1A1 P00352 7/20 0.43
GAA P10253 2/20 0.43
CA1 P00915 3/20 0.43
CA2 P00918 3/20 0.43
CA7 P43166 2/20 0.43
CA9 Q16790 2/20 0.43
CA4 P22748 1/20 0.43
DHODH Q02127 1/20 0.43
CYP2C19 P33261 2/20 0.41
MMP1 P03956 1/20 0.41
MMP2 P08253 1/20 0.41
MMP9 P14780 1/20 0.41
MMP8 P22894 1/20 0.41
MMP13 P45452 1/20 0.41
CYP3A4 P08684 1/20 0.41
CYP2C9 P11712 1/20 0.41
CYP2D6 P10635 1/20 0.41
CA12 O43570 1/20 0.41
CA3 P07451 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9484674 0.93 ALDH1A1 (0.43) STAT3ALDH1A1GAACA1CA2
SCHEMBL17480135 0.93 ALDH1A1 (0.43) STAT3ALDH1A1GAACA1CA2
SCHEMBL17929597 0.93 ALDH1A1 (0.43) STAT3ALDH1A1GAACA1CA2
SCHEMBL5471050 0.91 STAT3 (0.43) STAT3ALDH1A1GAACA1CA2
SCHEMBL115398 0.91 STAT3 (0.43) STAT3ALDH1A1GAACA1CA2
SCHEMBL5471045 0.91 STAT3 (0.43) STAT3ALDH1A1GAACA1CA2
SCHEMBL4621606 0.91 STAT3 (0.43) STAT3ALDH1A1GAACA1CA2
SCHEMBL2548351 0.91 STAT3 (0.43) STAT3ALDH1A1GAACA1CA2
SCHEMBL2548348 0.91 STAT3 (0.43) STAT3ALDH1A1GAACA1CA2
SCHEMBL25382784 0.90 CA1 (0.42) STAT3ALDH1A1GAACA1CA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12605471-B2 Cromolyn derivatives and related methods of imaging and treatment THE GENERAL HOSPITAL CORPORATION (US) 2026-04-21 US disclosed
US-20240058480-A1 CROMOLYN DERIVATIVES AND RELATED METHODS OF IMAGING AND TREATMENT THE GENERAL HOSPITAL CORPORATION 2024-02-22 US disclosed
US-11801316-B2 Cromolyn derivatives and related methods of imaging and treatment THE GENERAL HOSPITAL CORPORATION (US) 2023-10-31 US disclosed
US-11679095-B2 Macrophages/microglia in neuro-inflammation associated with neurodegenerative diseases THE GENERAL HOSPITAL CORPORATION (US) 2023-06-20 US disclosed
US-11666669-B2 Cromolyn derivatives and related methods of imaging and treatment THE GENERAL HOSPITAL CORPORATION (US) 2023-06-06 US disclosed
US-10738063-B2 6,7-dihydro-5H-pyrazolo[5,1-b][1,3]oxazine-2-carboxamide compounds PFIZER INC. (US) 2020-08-11 US disclosed
US-10576171-B2 Cromolyn derivatives and related methods of imaging and treatment THE GENERAL HOSPITAL CORPORATION (US) 2020-03-03 US disclosed
EP-3567033-A1 CROMOLYN DERIVATIVES AND RELATED METHODS OF IMAGING AND TREATMENT The General Hospital Corporation (US) 2019-11-13 EP disclosed
US-20190300546-A1 6,7-DIHYDRO-5H-PYRAZOLO[5,1-B][1,3]OXAZINE-2-CARBOXAMIDE COMPOUNDS PFIZER (US) 2019-10-03 US disclosed
US-20190231910-A1 CROMOLYN DERIVATIVES AND RELATED METHODS OF IMAGING AND TREATMENT THE GENERAL HOSPITAL CORPORATION 2019-08-01 US disclosed
WO-2015061397-A1 CROMOLYN DERIVATIVES AND RELATED METHODS OF IMAGING AND TREATMENT THE GENERAL HOSTPITAL CORPORATION (US) 2015-04-30 WO disclosed
US-20140140927-A1 CROMOLYN DERIVATIVES AND RELATED METHODS OF IMAGING AND TREATMENT THE GENERAL HOSPITAL CORPORATION (US) 2014-05-22 US disclosed
US-20140140927-A1 CROMOLYN DERIVATIVES AND RELATED METHODS OF IMAGING AND TREATMENT THE GENERAL HOSPITAL CORPORATION (US) 2014-05-22 US disclosed
US-8617517-B2 Cromolyn derivatives and related methods of imaging and treatment THE GENERAL HOSPITAL CORPORATION (US) 2013-12-31 US disclosed
US-20120058049-A1 CROMOLYN DERIVATIVES AND RELATED METHODS OF IMAGING AND TREATMENT THE GENERAL HOSPITAL CORPORATION 2012-03-08 US disclosed
US-20120058049-A1 CROMOLYN DERIVATIVES AND RELATED METHODS OF IMAGING AND TREATMENT THE GENERAL HOSPITAL CORPORATION 2012-03-08 US disclosed
WO-2010088455-A2 CROMOLYN DERIVATIVES AND RELATED METHODS OF IMAGING AND TREATMENT THE GENERAL HOSPITAL CORPORATION (US) 2010-08-05 WO disclosed
US-5886190-A REACTING GLYCEROL-1,3-DITOSYLATE-2-O-ACETYLATE WITH 2-NITROIMIDAZOLE TO FORM CHEMICAL INTERMEDIATE 1-(2'-NITRO-1'-IMIDAZOLYL)-2-O-ACETYL-3-O-TOSYLPROPANOL IN PRESENCE OF DIMETHYLFORMAMIDE AND CESIUM CARBONATE WALLACE SIDNEY (US) 1999-03-23 US disclosed
US-5728843-A POSITRON EMISSION TOMOGRAPHY(PET) TO DIFFERENTIATE METABOLICALLY ACTIVE HYPOXIC TUMOR CELLS WALLACE TECHNOLOGIES (US) 1998-03-17 US disclosed
WO-1995009844-A1 RAPID SYNTHESIS AND USE OF 18F-FLUOROMISONIDAZOLE AND ANALOGS BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 1995-04-13 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10576171-B2 Cromolyn derivatives and related methods of imaging and treatment PSEN1, PSEN2, CROCC STAT3 3477/4885ALDH1A1 3226/4885GAA 1692/4885
US-12605471-B2 Cromolyn derivatives and related methods of imaging and treatment PSEN1, APP, PSEN2 STAT3 1897/4885ALDH1A1 3176/4885GAA 4063/4885
US-11801316-B2 Cromolyn derivatives and related methods of imaging and treatment PSEN1, PSEN2, CROCC STAT3 3655/4885ALDH1A1 3040/4885GAA 1308/4885
US-20240058480-A1 CROMOLYN DERIVATIVES AND RELATED METHODS OF IMAGING AND TREATMENT PSEN1, PSEN2, CROCC STAT3 3642/4885ALDH1A1 3053/4885GAA 1525/4885
US-20190300546-A1 6,7-DIHYDRO-5H-PYRAZOLO[5,1-B][1,3]OXAZINE-2-CARBOXAMIDE COMPOUNDS PDE4B, PDE5A, PDE3B STAT3 3382/4885ALDH1A1 150/4885GAA 1441/4885
US-10738063-B2 6,7-dihydro-5H-pyrazolo[5,1-b][1,3]oxazine-2-carboxamide compounds PDE4B, PDE5A, PDE3B STAT3 3382/4885ALDH1A1 150/4885GAA 1441/4885
US-20190231910-A1 CROMOLYN DERIVATIVES AND RELATED METHODS OF IMAGING AND TREATMENT PSEN1, PSEN2, CROCC STAT3 3477/4885ALDH1A1 3226/4885GAA 1692/4885
US-11679095-B2 Macrophages/microglia in neuro-inflammation associated with neurodegenerative diseases CD68, PRNP, HTT STAT3 486/4885ALDH1A1 3735/4885GAA 613/4885
US-20140140927-A1 CROMOLYN DERIVATIVES AND RELATED METHODS OF IMAGING AND TREATMENT PSEN1, PSEN2, CROCC STAT3 3642/4885ALDH1A1 3053/4885GAA 1525/4885
US-20120058049-A1 CROMOLYN DERIVATIVES AND RELATED METHODS OF IMAGING AND TREATMENT CLN6, CA6, GALNT6 STAT3 3818/4885ALDH1A1 3021/4885GAA 2158/4885
US-11666669-B2 Cromolyn derivatives and related methods of imaging and treatment PSEN1, PSEN2, CROCC STAT3 3642/4885ALDH1A1 3053/4885GAA 1525/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.