Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 18/20 | 0.63 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.48 |
| ▸ | DPP4 | P27487 | 1/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19337949 | 1.00 | CCR2 (0.63) | CCR2KCNH2DPP4EPHX2 | |
| SCHEMBL18700148 | 0.85 | CCR2 (0.66) | CCR2KCNH2 | |
| SCHEMBL18699972 | 0.84 | CCR2 (0.68) | CCR2KCNH2 | |
| SCHEMBL18699978 | 0.84 | CCR2 (0.68) | CCR2KCNH2 | |
| SCHEMBL14629244 | 0.79 | CCR2 (0.69) | CCR2KCNH2 | |
| SCHEMBL14100774 | 0.79 | CCR2 (0.69) | CCR2KCNH2 | |
| SCHEMBL14101229 | 0.79 | CCR2 (0.46) | CCR2KCNH2DPP4EPHX2 | |
| SCHEMBL18901807 | 0.79 | CCR2 (0.61) | CCR2EPHX2 | |
| SCHEMBL15325921 | 0.78 | CCR2 (1.00) | CCR2KCNH2 | |
| SCHEMBL14101090 | 0.77 | CCR2 (0.66) | CCR2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1501803-B1 | TETRAHYDROPYRANYL CYCLOPENTYL TETRAHYDROISOQUINOLINE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | MERCK & CO INC (US) | 2008-08-13 | — | — | EP | disclosed |