Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 20/20 | 0.47 |
| ▸ | CCR5 | P51681 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14153659 | 0.83 | CCR2 (0.54) | CCR2CCR5 | |
| SCHEMBL14101062 | 0.83 | CCR2 (0.54) | CCR2CCR5 | |
| SCHEMBL14101059 | 0.83 | CCR2 (0.54) | CCR2CCR5 | |
| SCHEMBL14153658 | 0.82 | CCR2 (0.55) | CCR2CCR5 | |
| SCHEMBL14107337 | 0.82 | CCR2 (0.55) | CCR2CCR5 | |
| SCHEMBL14169252 | 0.78 | CCR2 (0.51) | CCR2CCR5 | |
| SCHEMBL14101155 | 0.78 | CCR2 (0.51) | CCR2CCR5 | |
| SCHEMBL4821868 | 0.77 | CCR2 (0.57) | CCR2CCR5 | |
| SCHEMBL14629204 | 0.71 | SMN1; SMN2 (0.33) | — | |
| SCHEMBL23200345 | 0.71 | ALDH1A1 (0.42) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1501803-B1 | TETRAHYDROPYRANYL CYCLOPENTYL TETRAHYDROISOQUINOLINE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | MERCK & CO INC (US) | 2008-08-13 | — | — | EP | disclosed |