Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 1/20 | 0.59 |
| ▸ | MAOB | P27338 | 1/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | RORC | P51449 | 7/20 | 0.50 |
| ▸ | ESR1 | P03372 | 3/20 | 0.50 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18456032 | 0.86 | KDM4E (0.53) | MAOAMAOBKDM4EPKMRORC | |
| SCHEMBL1787324 | 0.81 | KDM4E (0.48) | MAOAMAOBKDM4EPKMESR1 | |
| SCHEMBL15647424 | 0.80 | RORC (0.45) | MAOAMAOBKDM4EPKMRORC | |
| SCHEMBL15646540 | 0.79 | RORC (0.53) | KDM4EPKMRORCALDH1A1CYP1A2 | |
| SCHEMBL2720125 | 0.79 | RORC (0.53) | KDM4ERORCALDH1A1POLBMAPT | |
| SCHEMBL16645288 | 0.79 | RORC (0.56) | RORCESR1ESR2 | |
| SCHEMBL6679033 | 0.79 | MAOA (0.70) | MAOAMAOBKDM4EPKMTDP1 | |
| SCHEMBL4824018 | 0.78 | KDM4E (0.55) | KDM4ERORCESR1ESR2LMNA | |
| Water SCHEMBL27739698 | 0.77 | MAOA (0.67) | MAOAMAOBKDM4EPKMTDP1 | |
| SCHEMBL29175203 | 0.77 | MAOA (0.67) | MAOAMAOBKDM4EPKMTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105073729-A | Phenyl-linked quinolinyl modulators of ROR γ t | JANSSEN PHARMACEUTICA NV | 2015-11-18 | — | — | CN | disclosed |
| US-7405303-B2 | Substituted quinoline compounds for use as selective estrogen receptor modulator | SMITHKLINE BEECHAM CORPORATION (US) | 2008-07-29 | — | — | US | disclosed |
| US-20070203180-A1 | e.g. 4-[(7-Hydroxy-2-ethyl-3-phenyl-4-quinolinyl)oxyphenyl]-2-propenoic acid; bone diseases, aging, osteoporosis, osteoarthritis, atherosclerosis, menopausal disorders,liver and cardiovascular disorder, breast cancer | SMITHKLINE BEECHAM CORPORATION | 2007-08-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070203180-A1 | e.g. 4-[(7-Hydroxy-2-ethyl-3-phenyl-4-quinolinyl)oxyphenyl]-2-propenoic acid; bone diseases, aging, osteoporosis, osteoarthritis, atherosclerosis, menopausal disorders,liver and cardiovascular disorder, breast cancer | GPER1, ESRRG, ESR2 | MAOA 1250/4885MAOB 1485/4885KDM4E 2244/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.