Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 16/20 | 0.56 |
| ▸ | ESR1 | P03372 | 3/20 | 0.47 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.47 |
| ▸ | ESRRB | O95718 | 1/20 | 0.46 |
| ▸ | ESRRA | P11474 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16479373 | 0.83 | ESR1 (0.43) | RORCESR1ESR2ESRRBESRRA | |
| SCHEMBL16645240 | 0.81 | PDE4B (0.47) | RORCESR1ESR2ESRRBESRRA | |
| SCHEMBL16645260 | 0.81 | ESR1 (0.42) | RORCESR1ESR2ESRRBESRRA | |
| SCHEMBL16645170 | 0.81 | RORC (0.52) | RORCESR1ESR2ESRRBESRRA | |
| SCHEMBL2720125 | 0.81 | RORC (0.53) | RORC | |
| SCHEMBL15646540 | 0.81 | RORC (0.53) | RORC | |
| SCHEMBL14105877 | 0.79 | MAOA (0.59) | RORCESR1ESR2 | |
| SCHEMBL16633077 | 0.76 | RORC (0.49) | RORC | |
| SCHEMBL16474154 | 0.75 | RORC (0.92) | RORC | |
| SCHEMBL16645262 | 0.75 | RORC (0.41) | RORCESR1ESR2ESRRBESRRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160279122-A1 | PHENYL LINKED QUINOLINYL MODULATORS OF RORgammat | JANSSEN PHARMACEUTICA NV (BE) | 2016-09-29 | — | — | US | disclosed |
| US-9403816-B2 | Phenyl linked quinolinyl modulators of RORγt | JANSSEN PHARMACEUTICA NV (BE) | 2016-08-02 | — | — | US | disclosed |
| US-20150105404-A1 | PHENYL LINKED QUINOLINYL MODULATORS OF RORyt | JANSSEN PHARMACEUTICA NV (BE) | 2015-04-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160279122-A1 | PHENYL LINKED QUINOLINYL MODULATORS OF RORgammat | RORC, RORB, RORA | RORC 1/4885ESR1 1296/4885ESR2 427/4885 |
| US-20150105404-A1 | PHENYL LINKED QUINOLINYL MODULATORS OF RORyt | RORC, RORA, RORB | RORC 1/4885ESR1 1297/4885ESR2 653/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.