Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PYGL | P06737 | 11/20 | 0.54 |
| ▸ | PYGM | P11217 | 9/20 | 0.54 |
| ▸ | BRD4 | O60885 | 1/20 | 0.47 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.47 |
| ▸ | AHR | P35869 | 1/20 | 0.43 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | DRD4 | P21917 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.42 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.42 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13324479 | 0.83 | CREBBP (0.51) | PYGLPYGMBRD4CREBBPAHR | |
| SCHEMBL7344411 | 0.80 | PYGL (0.49) | PYGLPYGMBRD4CREBBPAHR | |
| SCHEMBL29900499 | 0.79 | PYGL (0.64) | PYGLPYGMBRD4CREBBPMAPT | |
| SCHEMBL15541576 | 0.79 | PYGL (0.64) | PYGLPYGMBRD4CREBBPMAPT | |
| SCHEMBL25329367 | 0.79 | PYGL (0.64) | PYGLPYGMBRD4CREBBPMAPT | |
| SCHEMBL651545 | 0.79 | PSEN1 (0.48) | PYGLPYGMBRD4CREBBP | |
| SCHEMBL2837105 | 0.78 | PYGL (0.60) | PYGLPYGMBRD4CREBBP | |
| SCHEMBL7422479 | 0.76 | PYGL (0.46) | PYGLPYGMBRD4CREBBPAHR | |
| SCHEMBL17827483 | 0.75 | PYGL (0.45) | PYGLPYGMBRD4CREBBPAHR | |
| SCHEMBL8274775 | 0.74 | CREBBP (0.39) | PYGLPYGMBRD4CREBBPMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7417152-B2 | 4-bromo-5-(2-chloro-benzoylamino)-1H-pyrazole-3-carboxylic acid amide derivatives and related compounds as bradykinin B1 receptor antagonists for the treatment of inflammatory diseases | ELAN PHARMACEUTICALS, INC. (US) | 2008-08-26 | — | — | US | disclosed |