Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PYGL | P06737 | 8/20 | 0.46 |
| ▸ | PYGM | P11217 | 6/20 | 0.46 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | AHR | P35869 | 1/20 | 0.38 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.37 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.37 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | DRD4 | P21917 | 1/20 | 0.36 |
| ▸ | RIPK1 | Q13546 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1270287 | 0.87 | PYGL (0.49) | PYGLPYGMNPC1MAPK13MAPK12 | |
| SCHEMBL1270286 | 0.87 | PYGL (0.49) | PYGLPYGMNPC1MAPK13MAPK12 | |
| SCHEMBL8889903 | 0.79 | GSK3B (0.36) | PYGLPYGMMAPTGAARIPK1 | |
| SCHEMBL14108161 | 0.76 | PYGL (0.54) | PYGLPYGMBRD4CREBBPHDAC1 | |
| SCHEMBL13324479 | 0.76 | CREBBP (0.51) | PYGLPYGMBRD4CREBBPAHR | |
| SCHEMBL30250544 | 0.76 | RIPK1 (0.49) | BRD4CREBBPHDAC1HDAC8HDAC6 | |
| SCHEMBL25329367 | 0.76 | PYGL (0.64) | PYGLPYGMBRD4CREBBPMAPT | |
| SCHEMBL15541576 | 0.76 | PYGL (0.64) | PYGLPYGMBRD4CREBBPMAPT | |
| SCHEMBL29900499 | 0.76 | PYGL (0.64) | PYGLPYGMBRD4CREBBPMAPT | |
| SCHEMBL7344411 | 0.74 | PYGL (0.49) | PYGLPYGMBRD4CREBBPHDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5594006-A | SUCH AS COLLEGENASE, STROMELYSIN; ANTICANCER AGENTS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1997-01-14 | — | — | US | disclosed |
| EP-0641323-A1 | CARBOSTYRIL DERIVATIVES AS MATRIX METALLOPROTEINASES INHIBITORS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1995-03-08 | — | — | EP | disclosed |
| WO-1994021612-A1 | CARBOSTYRIL DERIVATIVES AS MATRIX METALLOPROTEINASES INHIBITORS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1994-09-29 | — | — | WO | disclosed |