Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 20/20 | 0.44 |
| ▸ | OPRL1 | P41146 | 15/20 | 0.44 |
| ▸ | OGFRL1 | Q5TC84 | 6/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL735734 | 0.99 | OPRM1 (0.44) | OPRM1OPRL1OGFRL1OPRK1OPRD1 | |
| SCHEMBL3930989 | 0.89 | OPRM1 (0.44) | OPRM1OPRL1OGFRL1OPRK1OPRD1 | |
| SCHEMBL735512 | 0.88 | OPRM1 (0.44) | OPRM1OPRL1OGFRL1OPRK1OPRD1 | |
| SCHEMBL734295 | 0.87 | KDM4E (0.47) | OPRM1OPRL1OGFRL1OPRK1OPRD1 | |
| SCHEMBL734734 | 0.87 | ALDH1A1 (0.43) | OPRM1OPRL1OGFRL1OPRK1OPRD1 | |
| SCHEMBL734275 | 0.87 | OPRM1 (0.39) | OPRM1OPRL1OGFRL1OPRK1OPRD1 | |
| SCHEMBL735878 | 0.86 | KDM4E (0.47) | OPRM1OPRL1OGFRL1OPRK1OPRD1 | |
| SCHEMBL735043 | 0.86 | OPRM1 (0.45) | OPRM1OPRL1OGFRL1OPRK1OPRD1 | |
| Hydrochloric Acid SCHEMBL735584 | 0.85 | KDM4E (0.46) | OPRM1OPRL1OGFRL1OPRK1OPRD1 | |
| SCHEMBL734437 | 0.85 | OPRM1 (0.44) | OPRM1OPRL1OGFRL1OPRK1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2044016-B1 | 4-HETEROARYL-SUBSTITUTED 1-AMINOCYCLOHEXANE-1-AND CYCLOHEXENE-1-DERIVATIVES HAVING EFFECTS ON THE OPIOD RECEPTOR SYSTEM | GRUENENTHAL GMBH (DE) | 2012-12-05 | — | — | EP | claimed |
| EP-2044016-B1 | 4-HETEROARYL-SUBSTITUTED 1-AMINOCYCLOHEXANE-1-AND CYCLOHEXENE-1-DERIVATIVES HAVING EFFECTS ON THE OPIOD RECEPTOR SYSTEM | GRUENENTHAL GMBH (DE) | 2012-12-05 | — | — | EP | disclosed |