Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | CASP1 | P29466 | 1/20 | 0.47 |
| ▸ | CASP7 | P55210 | 1/20 | 0.47 |
| ▸ | EGFR | P00533 | 2/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 13/20 | 0.43 |
| ▸ | OPRL1 | P41146 | 8/20 | 0.43 |
| ▸ | OGFRL1 | Q5TC84 | 6/20 | 0.42 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL734526 | 0.90 | EGFR (0.47) | KDM4EALDH1A1GAAMAPTCASP1 | |
| SCHEMBL734734 | 0.87 | ALDH1A1 (0.43) | KDM4EALDH1A1OPRM1OPRL1OGFRL1 | |
| SCHEMBL3930989 | 0.87 | OPRM1 (0.44) | OPRM1OPRL1OGFRL1OPRD1OPRK1 | |
| SCHEMBL14110424 | 0.87 | OPRM1 (0.44) | OPRM1OPRL1OGFRL1OPRD1OPRK1 | |
| SCHEMBL735878 | 0.86 | KDM4E (0.47) | KDM4EALDH1A1OPRM1OPRL1OGFRL1 | |
| Hydrochloric Acid SCHEMBL735734 | 0.86 | OPRM1 (0.44) | OPRM1OPRL1OGFRL1OPRD1OPRK1 | |
| SCHEMBL735512 | 0.86 | OPRM1 (0.44) | OPRM1OPRL1OGFRL1OPRD1OPRK1 | |
| SCHEMBL734437 | 0.85 | OPRM1 (0.44) | KDM4EALDH1A1OPRM1OPRL1OGFRL1 | |
| Hydrochloric Acid SCHEMBL735584 | 0.85 | KDM4E (0.46) | KDM4EALDH1A1OPRM1OPRL1OGFRL1 | |
| SCHEMBL736019 | 0.85 | RAD52 (0.43) | OPRM1OPRL1OGFRL1OPRD1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2044016-B1 | 4-HETEROARYL-SUBSTITUTED 1-AMINOCYCLOHEXANE-1-AND CYCLOHEXENE-1-DERIVATIVES HAVING EFFECTS ON THE OPIOD RECEPTOR SYSTEM | GRUENENTHAL GMBH (DE) | 2012-12-05 | — | — | EP | disclosed |
| US-8138187-B2 | Substituted heteroaryl derivatives | GRUENENTHAL GMBH (DE) | 2012-03-20 | — | — | US | disclosed |
| US-20100009986-A1 | SUBSTITUTED HETEROARYL DERIVATIVES | GRUNENTHAL GMBH (DE) | 2010-01-14 | — | — | US | disclosed |
| EP-2044016-A2 | 4-HETEROARYL-SUBSTITUTED 1-AMINOCYCLOHEXANE-1-AND CYCLOHEXENE-1-DERIVATIVES HAVING EFFECTS ON THE OPIOD RECEPTOR SYSTEM | Grünenthal GmbH (DE) | 2009-04-08 | — | — | EP | disclosed |
| WO-2008009415-A2 | 4-HETEROARYL-SUBSTITUTED 1-AMINOCYCLOHEXANE-1- AND CYCLOHEXENE-1-DERIVATIVES HAVING EFFECTS ON THE OPIOD RECEPTOR SYSTEM | Grünenthal GmbH (DE) | 2008-01-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100009986-A1 | SUBSTITUTED HETEROARYL DERIVATIVES | CYP3A43, HMGCR, ABCG2 | KDM4E 2643/4885ALDH1A1 3171/4885GAA 534/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.