Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 2/20 | 0.76 |
| ▸ | F2 | P00734 | 1/20 | 0.71 |
| ▸ | PLG | P00747 | 1/20 | 0.71 |
| ▸ | PLAT | P00750 | 1/20 | 0.71 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.71 |
| ▸ | KLK1 | P06870 | 1/20 | 0.71 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.71 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.66 |
| ▸ | NPC1 | O15118 | 5/20 | 0.64 |
| ▸ | RAB9A | P51151 | 5/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.64 |
| ▸ | MEN1 | O00255 | 4/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.64 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.61 |
| ▸ | GPR27 | Q9NS67 | 1/20 | 0.61 |
| ▸ | CASP3 | P42574 | 1/20 | 0.60 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.60 |
| ▸ | HPSE | Q9Y251 | 1/20 | 0.59 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14111900 | 0.91 | MEN1 (0.71) | PLAUF2PLGPLATKLKB1 | |
| SCHEMBL2467402 | 0.91 | PLAU (0.78) | PLAUF2PLGPLATKLKB1 | |
| SCHEMBL14111903 | 0.90 | MEN1 (0.70) | PLAUNPC1RAB9AMEN1KMT2A | |
| SCHEMBL3656661 | 0.90 | DEGS1 (0.77) | PLAUF2PLGPLATKLKB1 | |
| SCHEMBL7325287 | 0.89 | KMT2A (0.78) | PLAUF2PLGPLATKLKB1 | |
| SCHEMBL6556069 | 0.86 | DEGS1 (0.77) | PLAUF2PLGPLATKLKB1 | |
| SCHEMBL14111907 | 0.86 | L3MBTL1 (0.71) | PLAUF2PLGPLATKLKB1 | |
| SCHEMBL26885648 | 0.85 | DEGS1 (0.70) | PLAUF2PLGPLATKLKB1 | |
| SCHEMBL11474161 | 0.85 | KMT2A (0.79) | NPC1RAB9AMEN1KMT2ANR1H4 | |
| Beta-Naphtoic Acid SCHEMBL11877084 | 0.84 | NPC1 (0.58) | PLAUF2PLGPLATKLKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8987474-B2 | Inhibition of Shp2/PTPN11 protein tyrosine phosphatase by NSC-87877, NSC-117199 and their analogs | UNIVERSITY OF SOUTH FLORIDA (US) | 2015-03-24 | — | — | US | disclosed |
| US-8987474-B2 | Inhibition of Shp2/PTPN11 protein tyrosine phosphatase by NSC-87877, NSC-117199 and their analogs | UNIVERSITY OF SOUTH FLORIDA (US) | 2015-03-24 | — | — | US | disclosed |
| US-20080176309-A1 | 8-hydroxy-7-(6-sulfonaphthalen-2-yl)diazenyl-quinoline-5-sulfonic acid (NSC-87877); Src homology-2 domains; Noonan syndrome, cancer | UNIVERSITY OF SOUTH FLORIDA (US) | 2008-07-24 | — | — | US | disclosed |
| US-20080176309-A1 | 8-hydroxy-7-(6-sulfonaphthalen-2-yl)diazenyl-quinoline-5-sulfonic acid (NSC-87877); Src homology-2 domains; Noonan syndrome, cancer | UNIVERSITY OF SOUTH FLORIDA (US) | 2008-07-24 | — | — | US | disclosed |
| WO-2007117699-A2 | INHIBITION OF SHP2/PTPN11 PROTEIN TYROSINE PHOSPHATASE BY NSC-87877, NSC-117199 AND THEIR ANALOGS | UNIVERSITY OF SOUTH FLORIDA (US) | 2007-10-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080176309-A1 | 8-hydroxy-7-(6-sulfonaphthalen-2-yl)diazenyl-quinoline-5-sulfonic acid (NSC-87877); Src homology-2 domains; Noonan syndrome, cancer | PTPN7, PTPN1, PTPN2 | PLAU 4650/4885F2 4882/4885PLG 4824/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.