Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 3/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.48 |
| ▸ | MMP9 | P14780 | 2/20 | 0.48 |
| ▸ | MMP8 | P22894 | 2/20 | 0.48 |
| ▸ | TTR | P02766 | 2/20 | 0.46 |
| ▸ | DPP4 | P27487 | 1/20 | 0.46 |
| ▸ | APP | P05067 | 3/20 | 0.44 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.44 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.44 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.44 |
| ▸ | MMP13 | P45452 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | JUN | P05412 | 2/20 | 0.40 |
| ▸ | IAPP | P10997 | 3/20 | 0.40 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.40 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | TOP2A | P11388 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12291328 | 0.87 | NFKB1 (0.45) | MMP2NFKB1MMP9MMP8TTR | |
| SCHEMBL13324421 | 0.85 | NFKB1 (0.61) | MMP2NFKB1MMP9MMP8APP | |
| SCHEMBL9972297 | 0.85 | MMP9 (0.62) | MMP2NFKB1MMP9MMP8TTR | |
| SCHEMBL9907026 | 0.84 | MAOB (0.63) | NFKB1MMP9TTRAPPAKR1B1 | |
| SCHEMBL14112805 | 0.84 | NFKB1 (0.54) | MMP2NFKB1MMP9MMP8APP | |
| SCHEMBL16888048 | 0.79 | NFKB1 (0.58) | MMP2NFKB1MMP9MMP8APP | |
| SCHEMBL9972306 | 0.78 | JUN (0.49) | NFKB1TTRDPP4APPMAOB | |
| SCHEMBL14898162 | 0.78 | TTR (0.74) | MMP2NFKB1MMP9MMP8TTR | |
| SCHEMBL11928816 | 0.77 | NFKB1 (0.65) | MMP2NFKB1MMP9MMP8APP | |
| SCHEMBL16884579 | 0.76 | TTR (0.63) | MMP2NFKB1MMP9MMP8TTR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080161391-A1 | NOVEL CURCUMIN ANALOGUES AND USES THEREOF | THE UNIVERSITY OF NORTH CAROLINA (US) | 2008-07-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080161391-A1 | NOVEL CURCUMIN ANALOGUES AND USES THEREOF | AR, NR5A1, BRDT | MMP2 2144/4885NFKB1 1410/4885MMP9 2476/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.