Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 6/20 | 0.51 |
| ▸ | RAB9A | P51151 | 6/20 | 0.51 |
| ▸ | HPGD | P15428 | 3/20 | 0.51 |
| ▸ | PKM | P14618 | 2/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.51 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.50 |
| ▸ | EGFR | P00533 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | GUSB | P08236 | 2/20 | 0.43 |
| ▸ | CPB1 | P15086 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | C1R | P00736 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | CASP3 | P42574 | 1/20 | 0.42 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.42 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29811008 | 1.00 | NPC1 (0.51) | NPC1RAB9AHPGDPKMHTT | |
| SCHEMBL6451424 | 0.86 | NPC1 (0.64) | NPC1RAB9AHPGDPKMHTT | |
| SCHEMBL29006460 | 0.78 | ACHE (0.45) | NPC1RAB9AHPGDKDM4EALDH1A1 | |
| SCHEMBL28632605 | 0.77 | NPC1 (0.59) | NPC1RAB9AHPGDPKMHTT | |
| SCHEMBL7729357 | 0.77 | NPC1 (0.59) | NPC1RAB9AHPGDEGFRKDM4E | |
| SCHEMBL29810999 | 0.77 | RAB9A (0.74) | NPC1RAB9AHPGDRXFP1NOTUM | |
| SCHEMBL2800972 | 0.77 | ALDH1A1 (0.51) | NPC1RAB9AHPGDPKMHTT | |
| SCHEMBL9059010 | 0.77 | NPC1 (0.74) | NPC1RAB9AHPGDNOTUMEGFR | |
| SCHEMBL14112946 | 0.77 | RAB9A (0.74) | NPC1RAB9AHPGDRXFP1NOTUM | |
| SCHEMBL29529901 | 0.77 | NPC1 (0.74) | NPC1RAB9AHPGDNOTUMEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113461630-B | Nootkatone thioether derivative containing 1,3, 4-oxadiazole ring, and preparation method and application thereof | 郑州大学 | 2022-09-02 | — | — | CN | claimed |
| CN-113461630-A | Nootkatone thioether derivative containing 1,3, 4-oxadiazole ring, and preparation method and application thereof | 郑州大学 | 2021-10-01 | — | — | CN | claimed |
| CN-113461630-B | Nootkatone thioether derivative containing 1,3, 4-oxadiazole ring, and preparation method and application thereof | 郑州大学 | 2022-09-02 | — | — | CN | disclosed |
| CN-113461630-A | Nootkatone thioether derivative containing 1,3, 4-oxadiazole ring, and preparation method and application thereof | 郑州大学 | 2021-10-01 | — | — | CN | disclosed |
| US-10851072-B2 | Inhibitors of Rho/MRTF/SRF-mediated gene transcription and methods for use of the same | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2020-12-01 | — | — | US | disclosed |
| US-10851072-B2 | Inhibitors of Rho/MRTF/SRF-mediated gene transcription and methods for use of the same | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2020-12-01 | — | — | US | disclosed |
| US-20190308947-A1 | INHIBITORS OF RHO/MRTF/SRF-MEDIATED GENE TRANSCRIPTION AND METHODS FOR USE OF THE SAME | THE REGENTS OF THE UNIVERSITY OF MICHIGAN | 2019-10-10 | — | — | US | disclosed |
| US-20190308947-A1 | INHIBITORS OF RHO/MRTF/SRF-MEDIATED GENE TRANSCRIPTION AND METHODS FOR USE OF THE SAME | THE REGENTS OF THE UNIVERSITY OF MICHIGAN | 2019-10-10 | — | — | US | disclosed |
| WO-2019195641-A2 | INHIBITORS OF RHO/MRTF/SRF-MEDIATED GENE TRANSCRIPTION AND METHODS FOR USE OF THE SAME | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2019-10-10 | — | — | WO | disclosed |
| WO-2019195641-A2 | INHIBITORS OF RHO/MRTF/SRF-MEDIATED GENE TRANSCRIPTION AND METHODS FOR USE OF THE SAME | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2019-10-10 | — | — | WO | disclosed |
| CN-105330651-B | 1 containing (miscellaneous) aryl and piperazine, 2,4- triazolinthione derivatives and preparation method and application | 南开大学 | 2018-05-01 | — | — | CN | disclosed |
| CN-105541748-B | 1,3,4 oxadiazole Mannich base class compounds and preparation and application containing piperazine | 南开大学 | 2017-09-12 | — | — | CN | disclosed |
| CN-105541748-A | Piperazine-contained 1,3,4-oxadiazole Mannich base compound, and preparation and application thereof | UNIV NANKAI | 2016-05-04 | — | — | CN | disclosed |
| CN-105330651-A | 1,2,4-Triazolethione derivative containing (hetero)aryl group and piperazine, and preparation method and application thereof | UNIV NANKAI | 2016-02-17 | — | — | CN | disclosed |
| US-20080160452-A1 | Developer for light sensitive planographic printing plate material and manufacturing process of planographic printing plate employing the same | KONICA MINOLTA MEDICAL & GRAPHIC, INC. (JP) | 2008-07-03 | — | — | US | disclosed |
| US-20080160452-A1 | Developer for light sensitive planographic printing plate material and manufacturing process of planographic printing plate employing the same | KONICA MINOLTA MEDICAL & GRAPHIC, INC. (JP) | 2008-07-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190308947-A1 | INHIBITORS OF RHO/MRTF/SRF-MEDIATED GENE TRANSCRIPTION AND METHODS FOR USE OF THE SAME | RHOXF2, BPTF, SREBF1 | NPC1 480/4885RAB9A 418/4885HPGD 1333/4885 |
| US-10851072-B2 | Inhibitors of Rho/MRTF/SRF-mediated gene transcription and methods for use of the same | RHOXF2, BPTF, SREBF1 | NPC1 480/4885RAB9A 418/4885HPGD 1333/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.