Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 1/20 | 0.64 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.55 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.55 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.55 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.55 |
| ▸ | TACR1 | P25103 | 2/20 | 0.55 |
| ▸ | HTR2A | P28223 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | HTR1A | P08908 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | HTR2C | P28335 | 2/20 | 0.52 |
| ▸ | HTR2B | P41595 | 2/20 | 0.52 |
| ▸ | BLM | P54132 | 2/20 | 0.52 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3853949 | 1.00 | SCN9A (0.64) | SCN9AGABRA1GABRB1GABRA3GABRB2 | |
| SCHEMBL5263791 | 1.00 | SCN9A (0.64) | SCN9AGABRA1GABRB1GABRA3GABRB2 | |
| Hydrochloric Acid SCHEMBL6300383 | 0.89 | SCN9A (0.54) | SCN9AGABRA1GABRB1GABRA3GABRB2 | |
| Hydrochloric Acid SCHEMBL6300382 | 0.89 | SCN9A (0.54) | SCN9AGABRA1GABRB1GABRA3GABRB2 | |
| SCHEMBL27659895 | 0.89 | MTNR1A (0.54) | SCN9AGABRA1GABRB1GABRA3GABRB2 | |
| SCHEMBL14066849 | 0.89 | MTNR1A (0.54) | SCN9AGABRA1GABRB1GABRA3GABRB2 | |
| SCHEMBL1197489 | 0.89 | MTNR1A (0.54) | SCN9AGABRA1GABRB1GABRA3GABRB2 | |
| Hydrochloric Acid SCHEMBL28558220 | 0.88 | MTNR1A (0.53) | SCN9AGABRA1GABRB1GABRA3GABRB2 | |
| Hydrochloric Acid SCHEMBL28173761 | 0.88 | MTNR1A (0.53) | SCN9AGABRA1GABRB1GABRA3GABRB2 | |
| SCHEMBL10407437 | 0.86 | NPSR1 (0.70) | SCN9ATACR1HTR2AKMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1732543-B1 | TETRACYCLIC CARBOLINE DERATIVES FOR INHIBITING ANGIOGENESIS | PTC THERAPEUTICS INC (US) | 2017-05-10 | — | — | EP | disclosed |
| US-8940896-B2 | Tetra-cyclic carboline derivatives useful in the inhibition of angiogenesis | PTC THERAPEUTICS, INC. (US) | 2015-01-27 | — | — | US | disclosed |
| US-8940896-B2 | Tetra-cyclic carboline derivatives useful in the inhibition of angiogenesis | PTC THERAPEUTICS, INC. (US) | 2015-01-27 | — | — | US | disclosed |
| US-20080182866-A1 | Tetra-Cyclic Carboline Derivatives Useful in the Inhibition of Angiogenesis | PTC THERAPEUTICS , INC. A CORPORATION | 2008-07-31 | — | — | US | disclosed |
| US-20080182866-A1 | Tetra-Cyclic Carboline Derivatives Useful in the Inhibition of Angiogenesis | PTC THERAPEUTICS , INC. A CORPORATION | 2008-07-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080182866-A1 | Tetra-Cyclic Carboline Derivatives Useful in the Inhibition of Angiogenesis | VEGFA, TEK, FLT4 | SCN9A 4870/4885GABRA1 4447/4885GABRB1 3862/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.