Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 1/20 | 0.64 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.55 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.55 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.55 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.55 |
| ▸ | TACR1 | P25103 | 2/20 | 0.55 |
| ▸ | HTR2A | P28223 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | HTR1A | P08908 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | HTR2C | P28335 | 2/20 | 0.52 |
| ▸ | HTR2B | P41595 | 2/20 | 0.52 |
| ▸ | BLM | P54132 | 2/20 | 0.52 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14116366 | 1.00 | SCN9A (0.64) | SCN9AGABRA1GABRB1GABRA3GABRB2 | |
| SCHEMBL3853949 | 1.00 | SCN9A (0.64) | SCN9AGABRA1GABRB1GABRA3GABRB2 | |
| Hydrochloric Acid SCHEMBL6300383 | 0.89 | SCN9A (0.54) | SCN9AGABRA1GABRB1GABRA3GABRB2 | |
| Hydrochloric Acid SCHEMBL6300382 | 0.89 | SCN9A (0.54) | SCN9AGABRA1GABRB1GABRA3GABRB2 | |
| SCHEMBL27659895 | 0.89 | MTNR1A (0.54) | SCN9AGABRA1GABRB1GABRA3GABRB2 | |
| SCHEMBL14066849 | 0.89 | MTNR1A (0.54) | SCN9AGABRA1GABRB1GABRA3GABRB2 | |
| SCHEMBL1197489 | 0.89 | MTNR1A (0.54) | SCN9AGABRA1GABRB1GABRA3GABRB2 | |
| Hydrochloric Acid SCHEMBL28558220 | 0.88 | MTNR1A (0.53) | SCN9AGABRA1GABRB1GABRA3GABRB2 | |
| Hydrochloric Acid SCHEMBL28173761 | 0.88 | MTNR1A (0.53) | SCN9AGABRA1GABRB1GABRA3GABRB2 | |
| SCHEMBL10407437 | 0.86 | NPSR1 (0.70) | SCN9ATACR1HTR2AKMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101103000-B | Carbazole, carboline and indole derivatives for inhibiting VEGF production | PTC THERAPEUTICS INC | 2012-06-27 | — | — | CN | disclosed |
| CN-101103000-A | Carbazole, carboline and indole derivatives for inhibiting VEGF production | PTC THERAPEUTICS INC (US) | 2008-01-09 | — | — | CN | disclosed |
| EP-1824821-A2 | CARBAZOLE, CARBOLINE AND INDOLE DERIVATIVES USEFUL IN THE INHIBITION OF VEGF PRODUCTION | PTC Therapeutics, Inc. (US) | 2007-08-29 | — | — | EP | disclosed |
| WO-2006058088-A2 | CARBAZOLE, CARBOLINE AND INDOLE DERIVATIVES USEFUL IN THE INHIBITION OF VEGF PRODUCTION | PTC THERAPEUTICS, INC. (US) | 2006-06-01 | — | — | WO | disclosed |