Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 1/20 | 0.54 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.54 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.53 |
| ▸ | HTR2A | P28223 | 4/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | HTR1A | P08908 | 3/20 | 0.53 |
| ▸ | HTR2C | P28335 | 3/20 | 0.53 |
| ▸ | HTR2B | P41595 | 3/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.53 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.53 |
| ▸ | HTR7 | P34969 | 1/20 | 0.53 |
| ▸ | MTOR | P42345 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27659895 | 1.00 | MTNR1A (0.54) | MTNR1AMTNR1BNR4A2HTR2AKMT2A | |
| SCHEMBL14066849 | 1.00 | MTNR1A (0.54) | MTNR1AMTNR1BNR4A2HTR2AKMT2A | |
| Hydrochloric Acid SCHEMBL28173761 | 0.99 | MTNR1A (0.53) | MTNR1AMTNR1BNR4A2HTR2AKMT2A | |
| Hydrochloric Acid SCHEMBL28558220 | 0.99 | MTNR1A (0.53) | MTNR1AMTNR1BNR4A2HTR2AKMT2A | |
| SCHEMBL14066853 | 0.90 | TACR1 (0.50) | NR4A2HTR2AKMT2AHTR1AHTR2C | |
| SCHEMBL5263791 | 0.89 | SCN9A (0.64) | MTNR1AMTNR1BNR4A2HTR2AKMT2A | |
| SCHEMBL3853949 | 0.89 | SCN9A (0.64) | MTNR1AMTNR1BNR4A2HTR2AKMT2A | |
| Hydrochloric Acid SCHEMBL27148566 | 0.89 | TACR1 (0.49) | NR4A2HTR2AKMT2AHTR1AHTR2C | |
| SCHEMBL14116366 | 0.89 | SCN9A (0.64) | MTNR1AMTNR1BNR4A2HTR2AKMT2A | |
| Hydrochloric Acid SCHEMBL27034726 | 0.89 | TACR1 (0.49) | NR4A2HTR2AKMT2AHTR1AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110027226-A1 | INDOLOPYRIDINES AS INHIBITORS OF THE KINESIN SPINDLE PROTEIN (EG5) | 4SC AG (DE) | 2011-02-03 | — | — | US | disclosed |
| EP-2033962-A1 | Tetracyclic indolopyridines as EG5 inhibitors | 4SC AG (DE) | 2009-03-11 | — | — | EP | disclosed |
| CN-1960725-A | Tetra-cyclic carboline derivatives useful in the inhibition of angiogenesis | PTC THERAPEUTICS INC (US) | 2007-05-09 | — | — | CN | disclosed |
| CN-1186344-C | Amino acid compounds and their use as NEP, ACE and ECE inhibitors | INST NAT RECH MEDICALE INSERM (FR) | 2005-01-26 | — | — | CN | disclosed |
| US-6716852-B2 | FOR THERAPY OF ARTERIAL HYPERTENSION AND CARDIOVASCULAR DISEASES | LES LABORATORIES SERVIER (FR) | 2004-04-06 | — | — | US | disclosed |
| US-20030055086-A1 | Amino acid derivatives and use thereof as nep, ace and ece inhibitors | LES LABORATOIRES SERVIER (FR) | 2003-03-20 | — | — | US | disclosed |
| CN-1400974-A | Amino acid derivatives and use thereof as NEP, ACE and ECE inhibitors | INST NAT RECH MEDICALE INSERM (FR) | 2003-03-05 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110027226-A1 | INDOLOPYRIDINES AS INHIBITORS OF THE KINESIN SPINDLE PROTEIN (EG5) | KIF5A, KIF5C, KIF5B | MTNR1A 3754/4885MTNR1B 4032/4885NR4A2 3443/4885 |
| US-20030055086-A1 | Amino acid derivatives and use thereof as nep, ace and ece inhibitors | MME, ACE, ECE1 | MTNR1A 333/4885MTNR1B 273/4885NR4A2 1672/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.