Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 6/20 | 0.58 |
| ▸ | LMNA | P02545 | 4/20 | 0.58 |
| ▸ | GAA | P10253 | 3/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | AKT1 | P31749 | 1/20 | 0.50 |
| ▸ | AKT2 | P31751 | 1/20 | 0.50 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.46 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6152409 | 0.85 | ALDH1A1 (0.56) | KDM4EL3MBTL1LMNAGAATDP1 | |
| SCHEMBL13950894 | 0.83 | KDM4E (0.78) | KDM4EL3MBTL1LMNAGAATDP1 | |
| SCHEMBL22769174 | 0.81 | KDM4E (0.75) | KDM4EL3MBTL1LMNAGAATDP1 | |
| SCHEMBL22769176 | 0.81 | KDM4E (0.75) | KDM4EL3MBTL1LMNAGAATDP1 | |
| SCHEMBL13726198 | 0.81 | KDM4E (0.75) | KDM4EL3MBTL1LMNAGAATDP1 | |
| SCHEMBL24590007 | 0.81 | KDM4E (0.75) | KDM4EL3MBTL1LMNAGAATDP1 | |
| SCHEMBL732131 | 0.81 | KDM4E (0.74) | KDM4EL3MBTL1LMNAGAATDP1 | |
| SCHEMBL29382173 | 0.81 | KDM4E (0.74) | KDM4EL3MBTL1LMNAGAATDP1 | |
| SCHEMBL14119243 | 0.81 | TAAR1 (0.63) | KDM4EL3MBTL1LMNAGAATDP1 | |
| SCHEMBL16981100 | 0.81 | KMT2A (0.63) | KDM4EL3MBTL1LMNAGAATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7396832-B2 | Inhibitors of Akt activity | MERCK & CO., INC. (US) | 2008-07-08 | — | — | US | disclosed |
| US-7396832-B2 | Inhibitors of Akt activity | MERCK & CO., INC. (US) | 2008-07-08 | — | — | US | disclosed |
| US-20070149536-A1 | Inhibitors of Akt activity | MERCK SHARP & DOHME CORP. | 2007-06-28 | — | — | US | disclosed |
| US-20070149536-A1 | Inhibitors of Akt activity | MERCK SHARP & DOHME CORP. | 2007-06-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070149536-A1 | Inhibitors of Akt activity | AKT1, AKT2, AKT3 | KDM4E 1347/4885L3MBTL1 2879/4885LMNA 4297/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.