Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 19/20 | 0.47 |
| ▸ | ADRB1 | P08588 | 16/20 | 0.47 |
| ▸ | ADRB3 | P13945 | 15/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.45 |
| ▸ | HTR2A | P28223 | 2/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.45 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.45 |
| ▸ | MLNR | O43193 | 1/20 | 0.45 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.45 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.45 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.45 |
| ▸ | DRD1 | P21728 | 1/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.45 |
| ▸ | MC3R | P41968 | 1/20 | 0.45 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.45 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.45 |
| ▸ | GHSR | Q92847 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23012741 | 1.00 | ADRB2 (0.47) | ADRB2ADRB1ADRB3SLC6A2HTR2A | |
| SCHEMBL20659853 | 0.84 | ADRB2 (0.68) | ADRB2ADRB1ADRB3SLC6A2HTR2A | |
| SCHEMBL164421 | 0.84 | ADRB2 (0.68) | ADRB2ADRB1ADRB3SLC6A2HTR2A | |
| SCHEMBL29515412 | 0.84 | ADRB2 (0.68) | ADRB2ADRB1ADRB3SLC6A2HTR2A | |
| SCHEMBL118139 | 0.81 | ADRB2 (0.66) | ADRB2ADRB1ADRB3SLC6A2HTR2A | |
| SCHEMBL23012291 | 0.81 | ADRB2 (0.66) | ADRB2ADRB1ADRB3SLC6A2HTR2A | |
| SCHEMBL31720778 | 0.76 | ADRB2 (0.55) | ADRB2ADRB1ADRB3SLC6A2HTR2A | |
| Vilanterol SCHEMBL164639 | 0.70 | ADRB2 (0.82) | ADRB2ADRB1ADRB3SLC6A2HTR2A | |
| Vilanterol SCHEMBL25268141 | 0.70 | ADRB2 (0.82) | ADRB2ADRB1ADRB3SLC6A2HTR2A | |
| Vilanterol SCHEMBL29352172 | 0.70 | ADRB2 (0.82) | ADRB2ADRB1ADRB3SLC6A2HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120309725-A1 | COMBINATIONS OF A MUSCARINIC RECEPTOR ANTAGONIST AND A BETA-2 ADRENORECEPTOR AGONIST | GLAXO GROUP LIMITED | 2012-12-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120309725-A1 | COMBINATIONS OF A MUSCARINIC RECEPTOR ANTAGONIST AND A BETA-2 ADRENORECEPTOR AGONIST | ADRB2, CHRM3, CHRNB2 | ADRB2 1/4885ADRB1 13/4885ADRB3 17/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.