SCHEMBL14123768

SCHEMBL14123768

C=CC(=O)OCCN(C(=O)N(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1

nearest known ligand 0.46

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
TACR1 P25103 12/20 0.46
THRB P10828 1/20 0.40
POLQ O75417 3/20 0.38
L3MBTL1 Q9Y468 1/20 0.37
P2RX1 P51575 1/20 0.36
ALDH1A1 P00352 2/20 0.35
KDM4E B2RXH2 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14123765 0.87 THRB (0.48) THRBL3MBTL1ALDH1A1
SCHEMBL14123772 0.86 THRB (0.45) THRBL3MBTL1ALDH1A1
SCHEMBL14123725 0.86 THRB (0.47) THRBL3MBTL1ALDH1A1
SCHEMBL14123740 0.83 THRB (0.42) THRBALDH1A1KDM4E
SCHEMBL14123767 0.81 THRB (0.54) THRBALDH1A1KDM4E
SCHEMBL14123743 0.80 THRB (0.46) THRBALDH1A1KDM4E
SCHEMBL14123746 0.80 THRB (0.41) THRBALDH1A1KDM4E
SCHEMBL14123739 0.80 TSHR (0.48) THRBKDM4E
SCHEMBL14123777 0.80 THRB (0.43) THRBALDH1A1KDM4E
SCHEMBL14123744 0.80 THRB (0.39) THRBL3MBTL1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8962227-B2 Electrophotographic photosensitive member, process cartridge, electrophotographic apparatus, method of producing electrophotographic photosensitive member, and urea compound CANON KABUSHIKI KAISHA (JP) 2015-02-24 US disclosed
US-20120301177-A1 ELECTROPHOTOGRAPHIC PHOTOSENSITIVE MEMBER, PROCESS CARTRIDGE, ELECTROPHOTOGRAPHIC APPARATUS, METHOD OF PRODUCING ELECTROPHOTOGRAPHIC PHOTOSENSITIVE MEMBER, AND UREA COMPOUND CANON KABUSHIKI KAISHA (JP) 2012-11-29 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120301177-A1 ELECTROPHOTOGRAPHIC PHOTOSENSITIVE MEMBER, PROCESS CARTRIDGE, ELECTROPHOTOGRAPHIC APPARATUS, METHOD OF PRODUCING ELECTROPHOTOGRAPHIC PHOTOSENSITIVE MEMBER, AND UREA COMPOUND SLC14A1, ITCH, UROD TACR1 2442/4885THRB 4300/4885POLQ 407/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.