Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 2/20 | 0.41 |
| ▸ | AKR1C3 | P42330 | 9/20 | 0.39 |
| ▸ | PDE8B | O95263 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.38 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.38 |
| ▸ | SELE | P16581 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1412577 | 0.92 | AKR1C3 (0.41) | METAP2AKR1C3PDE8BNPC1RAB9A | |
| SCHEMBL1412571 | 0.85 | ALOX15 (0.42) | METAP2AKR1C3PDE8BCNR2NPC1 | |
| SCHEMBL1412507 | 0.82 | NPC1 (0.39) | METAP2AKR1C3PDE8BCNR2NPC1 | |
| SCHEMBL1412552 | 0.80 | ALOX15 (0.43) | METAP2AKR1C3NPC1RAB9AALOX15 | |
| SCHEMBL1412545 | 0.77 | PDE8B (0.50) | AKR1C3PDE8BALOX15L3MBTL1AKR1C2 | |
| SCHEMBL1412603 | 0.76 | NPC1 (0.39) | METAP2AKR1C3CNR2NPC1RAB9A | |
| SCHEMBL1412463 | 0.74 | PDE8B (0.44) | AKR1C3PDE8BALOX15L3MBTL1AKR1C2 | |
| SCHEMBL8321396 | 0.74 | NPC1 (0.50) | NPC1RAB9AICAM1SELEMEN1 | |
| SCHEMBL24569973 | 0.71 | NPC1 (0.39) | NPC1RAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL28491918 | 0.70 | NPC1 (0.41) | NPC1RAB9AICAM1SELEMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1991542-B1 | HERBICIDAL ISOXAZOLINE COMPOUNDS | SYNGENTA LTD (GB) | 2011-03-16 | — | — | EP | disclosed |
| US-20100004128-A1 | HERBICIDAL ISOXAZOLINE COMPOUNDS | SYNGENTA CROP PROTECTION, INC. (US) | 2010-01-07 | — | — | US | disclosed |
| EP-1991542-A1 | HERBICIDAL ISOXAZOLINE COMPOUNDS | Syngenta Limited (GB) | 2008-11-19 | — | — | EP | disclosed |
| WO-2007096576-A1 | HERBICIDAL ISOXAZOLINE COMPOUNDS | SYNGENTA LIMITED (GB) | 2007-08-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100004128-A1 | HERBICIDAL ISOXAZOLINE COMPOUNDS | CYP4X1, RDX, HAX1 | METAP2 3914/4885AKR1C3 340/4885PDE8B 1342/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.