Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE8B | O95263 | 1/20 | 0.44 |
| ▸ | AKR1C3 | P42330 | 10/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | TOP2A | P11388 | 1/20 | 0.42 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.41 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.39 |
| ▸ | FEN1 | P39748 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1412502 | 0.90 | AKR1C3 (0.45) | PDE8BAKR1C3ALOX15L3MBTL1TOP2A | |
| SCHEMBL1412545 | 0.84 | PDE8B (0.50) | PDE8BAKR1C3ALOX15L3MBTL1TOP2A | |
| SCHEMBL1412575 | 0.82 | ALOX15 (0.48) | PDE8BAKR1C3ALOX15L3MBTL1TOP2A | |
| SCHEMBL1412581 | 0.76 | ALOX15 (0.50) | PDE8BAKR1C3ALOX15L3MBTL1TOP2A | |
| SCHEMBL1412414 | 0.74 | METAP2 (0.41) | PDE8BAKR1C3ALOX15L3MBTL1PTGER4 | |
| SCHEMBL1412426 | 0.73 | AKR1C3 (0.51) | PDE8BAKR1C3ALOX15L3MBTL1TOP2A | |
| SCHEMBL15946997 | 0.73 | PTGER4 (0.66) | AKR1C3TOP2APTGER4MEN1KMT2A | |
| SCHEMBL22816865 | 0.72 | AKR1C3 (0.50) | PDE8BAKR1C3ALOX15L3MBTL1TOP2A | |
| SCHEMBL17963226 | 0.71 | CYP19A1 (0.61) | MEN1KMT2A | |
| SCHEMBL3731878 | 0.71 | UCHL1 (0.54) | PDE8BAKR1C3ALOX15L3MBTL1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1991542-B1 | HERBICIDAL ISOXAZOLINE COMPOUNDS | SYNGENTA LTD (GB) | 2011-03-16 | — | — | EP | disclosed |
| US-20100004128-A1 | HERBICIDAL ISOXAZOLINE COMPOUNDS | SYNGENTA CROP PROTECTION, INC. (US) | 2010-01-07 | — | — | US | disclosed |
| US-20100004128-A1 | HERBICIDAL ISOXAZOLINE COMPOUNDS | SYNGENTA CROP PROTECTION, INC. (US) | 2010-01-07 | — | — | US | disclosed |
| US-20100004128-A1 | HERBICIDAL ISOXAZOLINE COMPOUNDS | SYNGENTA CROP PROTECTION, INC. (US) | 2010-01-07 | — | — | US | disclosed |
| EP-1991542-A1 | HERBICIDAL ISOXAZOLINE COMPOUNDS | Syngenta Limited (GB) | 2008-11-19 | — | — | EP | disclosed |
| WO-2007096576-A1 | HERBICIDAL ISOXAZOLINE COMPOUNDS | SYNGENTA LIMITED (GB) | 2007-08-30 | — | — | WO | disclosed |
| WO-2007096576-A1 | HERBICIDAL ISOXAZOLINE COMPOUNDS | SYNGENTA LIMITED (GB) | 2007-08-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100004128-A1 | HERBICIDAL ISOXAZOLINE COMPOUNDS | CYP4X1, RDX, HAX1 | PDE8B 1342/4885AKR1C3 340/4885ALOX15 2655/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.