Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.37 |
| ▸ | MAOA | P21397 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | GALR1 | P47211 | 1/20 | 0.36 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.35 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.35 |
| ▸ | PIM1 | P11309 | 1/20 | 0.33 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.33 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.33 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.33 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.33 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29656653 | 0.78 | ALDH1A1 (0.43) | ALDH1A1CYP2A6MAOAMAOBPOLB | |
| SCHEMBL11116210 | 0.78 | PTPN1 (0.44) | ALDH1A1CYP2A6MAOAMAOBPOLB | |
| SCHEMBL31678641 | 0.78 | ALDH1A1 (0.39) | SMN1; SMN2ALDH1A1CYP2A6MAOAMAOB | |
| SCHEMBL3734647 | 0.78 | ALDH1A1 (0.43) | ALDH1A1CYP2A6MAOAMAOBPOLB | |
| SCHEMBL29731873 | 0.75 | ALDH1A1 (0.38) | SMN1; SMN2HSD11B1ALDH1A1CYP2A6MAOA | |
| SCHEMBL21733906 | 0.75 | PTPN1 (0.44) | GAASMN1; SMN2ALDH1A1POLBGALR1 | |
| SCHEMBL678904 | 0.75 | L3MBTL1 (0.51) | ALDH1A1GALR1MAPTPTPRC | |
| SCHEMBL29533046 | 0.75 | PTPN1 (0.44) | GAASMN1; SMN2ALDH1A1POLBGALR1 | |
| SCHEMBL679561 | 0.74 | NPC1 (0.47) | ALDH1A1POLBMAPT | |
| SCHEMBL23645701 | 0.73 | MAPT (0.31) | ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022156761-A1 | SPIROCYCLIC INDENES | ASCENTAGE PHARMA (SUZHOU) CO., LTD. (CN) | 2022-07-28 | — | — | WO | disclosed |
| EP-1582524-B1 | Method of preparing organomagnesium compounds | UNIV MUENCHEN L MAXIMILIANS (DE) | 2008-08-13 | — | — | EP | disclosed |
| US-7387751-B2 | Method of preparing organomagnesium compounds | LUDWIG-MAXIMILIANS-UNIVERSITAT MUNCHEN (DE) | 2008-06-17 | — | — | US | disclosed |
| US-7387751-B2 | Method of preparing organomagnesium compounds | LUDWIG-MAXIMILIANS-UNIVERSITAT MUNCHEN (DE) | 2008-06-17 | — | — | US | disclosed |
| US-7384580-B2 | Method of preparing organomagnesium compounds | LUDWIG-MAXIMILIANS-UNIVERSITAT MUNCHEN (DE) | 2008-06-10 | — | — | US | disclosed |
| US-7384580-B2 | Method of preparing organomagnesium compounds | LUDWIG-MAXIMILIANS-UNIVERSITAT MUNCHEN (DE) | 2008-06-10 | — | — | US | disclosed |
| US-20070194468-A1 | Method of preparing organomagnesium compounds | LUDWIG-MAXIMILIANS-UNIVERSITAT MUNCHEN (DE) | 2007-08-23 | — | — | US | disclosed |
| US-20070194468-A1 | Method of preparing organomagnesium compounds | LUDWIG-MAXIMILIANS-UNIVERSITAT MUNCHEN (DE) | 2007-08-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070194468-A1 | Method of preparing organomagnesium compounds | SCLY, LIG3, LIG4 | GAA 1692/4885SMN1; SMN2 4369/4885HSD11B1 552/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.