Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 8/20 | 0.47 |
| ▸ | IL1B | P01584 | 6/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.46 |
| ▸ | NAMPT | P43490 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14127685 | 0.91 | IL1B (0.48) | P2RX7IL1BNPC1RAB9A | |
| SCHEMBL14127550 | 0.91 | P2RX7 (0.48) | P2RX7IL1BEPHX2NAMPTNPC1 | |
| SCHEMBL14127453 | 0.88 | RAB9A (0.43) | P2RX7EPHX2NPC1RAB9AL3MBTL1 | |
| SCHEMBL177987 | 0.88 | EPHX2 (0.46) | P2RX7IL1BEPHX2NAMPTNPC1 | |
| SCHEMBL177798 | 0.88 | EPHX2 (0.46) | P2RX7IL1BEPHX2NAMPTNPC1 | |
| SCHEMBL14127435 | 0.86 | EPHX2 (0.41) | P2RX7IL1BEPHX2NAMPTNPC1 | |
| SCHEMBL14127526 | 0.86 | EPHX2 (0.41) | P2RX7IL1BEPHX2NAMPTNPC1 | |
| SCHEMBL14127555 | 0.85 | P2RX7 (0.42) | P2RX7IL1BEPHX2NAMPTNPC1 | |
| SCHEMBL12704324 | 0.85 | EPHX2 (0.47) | P2RX7IL1BEPHX2NAMPTNPC1 | |
| SCHEMBL14127508 | 0.85 | P2RX7 (0.41) | P2RX7IL1BEPHX2NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012163456-A1 | NOVEL P2X7R ANTAGONISTS AND THEIR USE | AFFECTIS PHARMACEUTICALS AG (DE) | 2012-12-06 | — | — | WO | claimed |
| WO-2012163456-A1 | NOVEL P2X7R ANTAGONISTS AND THEIR USE | AFFECTIS PHARMACEUTICALS AG (DE) | 2012-12-06 | — | — | WO | disclosed |
| WO-2012163456-A1 | NOVEL P2X7R ANTAGONISTS AND THEIR USE | AFFECTIS PHARMACEUTICALS AG (DE) | 2012-12-06 | — | — | WO | disclosed |