Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | DNM1 | Q05193 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | SLC16A3 | O15427 | 2/20 | 0.47 |
| ▸ | SLC16A1 | P53985 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | APP | P05067 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12633782 | 0.94 | APP (0.51) | MAPTDNM1ALDH1A1MEN1KMT2A | |
| SCHEMBL14129171 | 0.90 | MEN1 (0.60) | MAPTDNM1ALDH1A1MEN1KMT2A | |
| SCHEMBL15371855 | 0.87 | ALDH1A1 (0.53) | MAPTALDH1A1MEN1KMT2APOLB | |
| SCHEMBL14129149 | 0.86 | MEN1 (0.57) | MAPTDNM1ALDH1A1MEN1KMT2A | |
| SCHEMBL15491698 | 0.86 | MAPT (0.46) | MAPTDNM1ALDH1A1MEN1KMT2A | |
| SCHEMBL17732471 | 0.86 | APP (0.45) | MAPTDNM1ALDH1A1MEN1KMT2A | |
| SCHEMBL17732481 | 0.85 | SLC16A3 (0.45) | MAPTDNM1ALDH1A1MEN1KMT2A | |
| SCHEMBL15491090 | 0.84 | SLC16A3 (0.46) | MAPTDNM1ALDH1A1MEN1KMT2A | |
| SCHEMBL1781017 | 0.84 | SLC16A3 (0.55) | MAPTALDH1A1MEN1KMT2APOLB | |
| SCHEMBL1781014 | 0.84 | SLC16A3 (0.55) | MAPTALDH1A1MEN1KMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180126008-A1 | Methods Of Preparing Ophthalmic Formulations And Uses Of Same | COGNOPTIX, INC. | 2018-05-10 | — | — | US | disclosed |
| US-20170315137-A1 | AMYLOID BINDING AGENTS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2017-11-02 | — | — | US | disclosed |
| US-9551722-B2 | Amyloid binding agents | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2017-01-24 | — | — | US | disclosed |
| US-20160278677-A1 | Method for Measuring Fluorescence in Ocular Tissue | COGNOPTIX, INC. | 2016-09-29 | — | — | US | disclosed |
| US-20150177262-A1 | AMYLOID BINDING AGENTS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2015-06-25 | — | — | US | disclosed |
| US-20150118163-A1 | Methods of Preparing Ophthalmic Formulations and Uses of Same | COGNOPTIX, INC. | 2015-04-30 | — | — | US | disclosed |
| US-20120302603-A1 | AMYLOID BINDING AGENTS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2012-11-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120302603-A1 | AMYLOID BINDING AGENTS | APP, APBA1, PSEN1 | MAPT 6/4885DNM1 1564/4885ALDH1A1 3897/4885 |
| US-20170315137-A1 | AMYLOID BINDING AGENTS | APBA1, APP, PSEN1 | MAPT 5/4885DNM1 1359/4885ALDH1A1 4267/4885 |
| US-20160278677-A1 | Method for Measuring Fluorescence in Ocular Tissue | ALDH1A2, FUCA1, EYA3 | MAPT 2162/4885DNM1 277/4885ALDH1A1 673/4885 |
| US-20180126008-A1 | Methods Of Preparing Ophthalmic Formulations And Uses Of Same | PDE6G, PDE6A, F12 | MAPT 318/4885DNM1 1335/4885ALDH1A1 1932/4885 |
| US-20150118163-A1 | Methods of Preparing Ophthalmic Formulations and Uses of Same | PDE6G, PDE6A, F12 | MAPT 318/4885DNM1 1335/4885ALDH1A1 1932/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.