Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 8/20 | 0.66 |
| ▸ | FLT1 | P17948 | 7/20 | 0.66 |
| ▸ | FLT4 | P35916 | 7/20 | 0.66 |
| ▸ | VCP | P55072 | 6/20 | 0.56 |
| ▸ | SIRT7 | Q9NRC8 | 1/20 | 0.55 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.55 |
| ▸ | IMPDH2 | P12268 | 2/20 | 0.51 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.48 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21311902 | 0.91 | VCP (0.68) | KDRFLT1FLT4VCPSIRT7 | |
| SCHEMBL21311878 | 0.86 | VCP (0.64) | KDRFLT1FLT4VCPSIRT7 | |
| SCHEMBL14057525 | 0.84 | TRPV1 (0.66) | KDRFLT1FLT4VCPSIRT7 | |
| SCHEMBL14058473 | 0.84 | KDR (0.67) | KDRFLT1FLT4VCPSIRT7 | |
| SCHEMBL1909825 | 0.81 | KDR (0.49) | KDRFLT1FLT4VCPSIRT7 | |
| SCHEMBL5184578 | 0.80 | KDR (0.72) | KDRFLT1FLT4VCPIMPDH2 | |
| Gw632046X SCHEMBL5475472 | 0.80 | KDR (1.00) | KDRFLT1FLT4VCPSIRT7 | |
| SCHEMBL14058062 | 0.78 | IMPDH2 (0.66) | KDRFLT1FLT4VCPSIRT7 | |
| SCHEMBL21311881 | 0.77 | VCP (0.78) | KDRFLT1FLT4VCPIMPDH2 | |
| SCHEMBL14134241 | 0.76 | KDR (0.73) | KDRFLT1FLT4SIRT7ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8865709-B2 | Aminooxazole inhibitors of cyclin dependent kinases | Neosome Life Sciences, LLC (US) | 2014-10-21 | — | — | US | disclosed |
| US-20140051694-A1 | Aminooxazole Inhibitors of Cyclin Dependent Kinases | Neosome Life Sciences, LLC (US) | 2014-02-20 | — | — | US | disclosed |
| US-8551992-B2 | Aminooxazole inhibitors of cyclin dependent kinases | Neosome Life Sciences, LLC (US) | 2013-10-08 | — | — | US | disclosed |
| US-8546400-B2 | 1,3-Oxazole-4-carboxamides, 1,3-Thiazole-4-carboxamides, and 1,3-Imidazole-d-carboxamides as Inhibitors of cyclin Dependent kinases | Neosome Life Sciences, LLC (US) | 2013-10-01 | — | — | US | disclosed |
| US-20130184288-A1 | Aminooxazole Inhibitors of Cyclin Dependent Kinases | Neosome Life Sciences, LLC (US) | 2013-07-18 | — | — | US | disclosed |
| US-20120302578-A1 | Aminooxazole Inhibitors of Cyclin Dependent Kinases | Neosome Life Sciences, LLC (US) | 2012-11-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130184288-A1 | Aminooxazole Inhibitors of Cyclin Dependent Kinases | CDK1, CCNK, CCNI | KDR 3471/4885FLT1 1646/4885FLT4 1762/4885 |
| US-20120302578-A1 | Aminooxazole Inhibitors of Cyclin Dependent Kinases | CDK1, CCNK, CCNI | KDR 3471/4885FLT1 1646/4885FLT4 1762/4885 |
| US-20140051694-A1 | Aminooxazole Inhibitors of Cyclin Dependent Kinases | CDK1, CCNK, CCNI | KDR 3471/4885FLT1 1646/4885FLT4 1762/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.