Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 19/20 | 0.50 |
| ▸ | TDP2 | O95551 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14137079 | 0.84 | DGAT1 (0.69) | DGAT1 | |
| SCHEMBL14062046 | 0.84 | DGAT1 (0.46) | DGAT1TDP2 | |
| SCHEMBL14137109 | 0.83 | DGAT1 (0.49) | DGAT1 | |
| SCHEMBL14137083 | 0.82 | DGAT1 (0.70) | DGAT1 | |
| SCHEMBL14060558 | 0.80 | DGAT1 (0.74) | DGAT1 | |
| SCHEMBL14060252 | 0.76 | DGAT1 (0.78) | DGAT1 | |
| SCHEMBL14060035 | 0.76 | DGAT1 (0.81) | DGAT1 | |
| SCHEMBL14059600 | 0.75 | DGAT1 (0.63) | DGAT1 | |
| SCHEMBL14137107 | 0.74 | DGAT1 (0.79) | DGAT1 | |
| SCHEMBL18746423 | 0.73 | EPHX2 (0.40) | DGAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012162127-A1 | NOVEL COMPOUNDS AS DIACYLGLYCEROL ACYLTRANSFERASE INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2012-11-29 | — | — | WO | disclosed |