Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | ACMSD | Q8TDX5 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | KMO | O15229 | 1/20 | 0.37 |
| ▸ | DGAT1 | O75907 | 8/20 | 0.37 |
| ▸ | MITF | O75030 | 1/20 | 0.37 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.37 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.37 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | PPARA | Q07869 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18746424 | 0.85 | EPHX2 (0.40) | EPHX2ACMSDCYP3A4KMODGAT1 | |
| SCHEMBL14137104 | 0.73 | DGAT1 (0.50) | DGAT1 | |
| SCHEMBL11674766 | 0.73 | ACMSD (0.41) | EPHX2ACMSDCYP3A4KMOMITF | |
| SCHEMBL19443174 | 0.72 | DGAT1 (0.53) | ACMSDDGAT1 | |
| SCHEMBL19443179 | 0.72 | DGAT1 (0.53) | ACMSDDGAT1 | |
| SCHEMBL19443209 | 0.72 | DGAT1 (0.53) | ACMSDDGAT1 | |
| SCHEMBL14137109 | 0.70 | DGAT1 (0.49) | DGAT1 | |
| SCHEMBL11674977 | 0.69 | TACR1 (0.41) | EPHX2ACMSDKMOMITFKLF5 | |
| SCHEMBL1740476 | 0.68 | EPHX2 (0.40) | EPHX2ACMSDCYP3A4PDK2 | |
| SCHEMBL1740480 | 0.67 | EPHX2 (0.38) | EPHX2CYP3A4PDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9624174-B2 | Compounds as diacylglycerol acyltransferase inhibitors | GLAXOSMITHKLINE LLC (US) | 2017-04-18 | — | — | US | disclosed |