Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SOAT1 | P35610 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 5/20 | 0.44 |
| ▸ | MAOA | P21397 | 4/20 | 0.44 |
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
| ▸ | F2 | P00734 | 2/20 | 0.39 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.38 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.38 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.38 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4056401 | 0.87 | SIGMAR1 (0.46) | MAOASLC6A2TAAR1SLC6A4SLC6A3 | |
| SCHEMBL7006959 | 0.82 | ESR1 (0.47) | SLC6A2TAAR1SIGMAR1 | |
| SCHEMBL5023592 | 0.81 | SOAT1 (0.41) | SOAT1MAOBMAOAPDE4AF2 | |
| Bicarbonate SCHEMBL28105724 | 0.80 | EPHX1 (0.49) | RAB9ANPC1 | |
| SCHEMBL14119146 | 0.78 | SLC7A5 (0.48) | RAB9ANPC1TAAR1SIGMAR1GAA | |
| SCHEMBL27608757 | 0.78 | SOAT1 (0.51) | SOAT1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL28131612 | 0.76 | SIGMAR1 (0.48) | SIGMAR1 | |
| SCHEMBL8732205 | 0.76 | TAAR1 (0.52) | SOAT1MAOBMAOARAB9ANPC1 | |
| SCHEMBL730661 | 0.75 | SLC6A2 (0.53) | SOAT1MAOBMAOAPDE4ASLC6A2 | |
| SCHEMBL12665322 | 0.75 | SLC6A4 (0.44) | MAOBMAOARAB9ANPC1SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1332133-B1 | METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS | JANSSEN PHARMACEUTICA NV (BE) | 2008-07-09 | — | — | EP | disclosed |