Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM1 | Q13255 | 3/20 | 0.48 |
| ▸ | PSMB5 | P28074 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | PDE10A | Q9Y233 | 4/20 | 0.42 |
| ▸ | NCK1 | P16333 | 1/20 | 0.42 |
| ▸ | BACE1 | P56817 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13597686 | 0.85 | MEN1 (0.54) | GRM1PSMB5MEN1KMT2ACYP1A2 | |
| SCHEMBL12570780 | 0.73 | CYP1A2 (0.55) | GRM1PSMB5MEN1KMT2ACYP1A2 | |
| SCHEMBL862359 | 0.72 | MEN1 (0.56) | PSMB5MEN1KMT2ACYP1A2NCK1 | |
| SCHEMBL1537768 | 0.72 | CYP2A6 (0.61) | CYP1A2MAPTKDM4E | |
| SCHEMBL12000236 | 0.71 | MAPT (0.58) | GRM1MEN1KMT2ACYP1A2MAPT | |
| SCHEMBL2371400 | 0.71 | CYP1A2 (0.62) | PSMB5MEN1KMT2ACYP1A2NCK1 | |
| SCHEMBL22296337 | 0.70 | ALDH1A1 (0.54) | GRM1MEN1KMT2ACYP1A2MAPT | |
| SCHEMBL19255198 | 0.70 | CYP1A2 (0.43) | PSMB5MEN1KMT2ACYP1A2PDE10A | |
| SCHEMBL12677805 | 0.70 | ALDH1A1 (0.54) | GRM1MEN1KMT2AKDM4E | |
| SCHEMBL8177959 | 0.69 | ALDH1A1 (0.62) | PSMB5MEN1KMT2ACYP1A2NCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1332133-B1 | METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS | JANSSEN PHARMACEUTICA NV (BE) | 2008-07-09 | — | — | EP | disclosed |