Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.54 |
| ▸ | NCK1 | P16333 | 1/20 | 0.50 |
| ▸ | BACE1 | P56817 | 1/20 | 0.50 |
| ▸ | CYP2A6 | P11509 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | NQO2 | P16083 | 1/20 | 0.45 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.44 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.44 |
| ▸ | PDE2A | O00408 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | MITF | O75030 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL862486 | 0.82 | ALDH1A1 (0.56) | MEN1KMT2ACYP1A2NCK1BACE1 | |
| SCHEMBL2371400 | 0.80 | CYP1A2 (0.62) | MEN1KMT2APSMB5CYP1A2NCK1 | |
| SCHEMBL862247 | 0.80 | CYP1A2 (0.52) | MEN1KMT2APSMB5CYP1A2NCK1 | |
| SCHEMBL8643542 | 0.78 | ALDH1A1 (0.49) | MEN1KMT2AKDM4EMAPTALDH1A1 | |
| SCHEMBL27910453 | 0.78 | TTR (0.46) | MEN1KMT2AKDM4EMAPTALDH1A1 | |
| SCHEMBL12827021 | 0.78 | TSHR (0.51) | MEN1KMT2ABACE1KDM4EMAPT | |
| SCHEMBL12500744 | 0.78 | KDM4E (0.57) | MEN1KMT2AKDM4EMAPTALDH1A1 | |
| SCHEMBL25675441 | 0.78 | PSMB5 (0.37) | MEN1KMT2APSMB5CYP1A2KDM4E | |
| SCHEMBL3835603 | 0.78 | CYP1A2 (0.50) | MEN1KMT2APSMB5CYP1A2NCK1 | |
| SCHEMBL8177959 | 0.78 | ALDH1A1 (0.62) | MEN1KMT2APSMB5CYP1A2NCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 54 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020205867-A1 | COMPOUNDS TARGETING PRMT5 | ALIGOS THERAPEUTICS, INC. (US) | 2020-10-08 | — | — | WO | disclosed |
| EP-2880080-B1 | POLYMERS, POLYMER MEMBRANES AND METHODS OF PRODUCING THE SAME | AIR PROD & CHEM (US) | 2018-07-04 | — | — | EP | disclosed |
| US-20180053868-A1 | PHOTOELECTRIC CONVERSION DEVICE HAVING REFLECTION PLATE | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2018-02-22 | — | — | US | disclosed |
| US-20180053868-A1 | PHOTOELECTRIC CONVERSION DEVICE HAVING REFLECTION PLATE | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2018-02-22 | — | — | US | disclosed |
| US-20170162808-A1 | PHOTOELECTRIC CONVERSION DEVICE | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2017-06-08 | — | — | US | disclosed |
| US-20170162808-A1 | PHOTOELECTRIC CONVERSION DEVICE | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2017-06-08 | — | — | US | disclosed |
| US-20170029367-A1 | Substituted Aromatic Sulfur Compounds and Methods of Their Use | CEPHALON INC (US) | 2017-02-02 | — | — | US | disclosed |
| US-20160372675-A1 | MACROMOLECULAR COMPOUND | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2016-12-22 | — | — | US | disclosed |
| US-9512149-B2 | Reactive compound | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2016-12-06 | — | — | US | disclosed |
| US-9512149-B2 | Reactive compound | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2016-12-06 | — | — | US | disclosed |
| US-4981978-A | Reaction products of imidazole on pyrazole derivatives and 4-isopropenyl-1-cyclohexene-1-carboxaldehyde | THE DOW CHEMICAL COMPANY (US) | 1991-01-01 | — | — | US | disclosed |
| US-4927932-A | Reaction products of pyrimidine, pyridazine and 4-isopropenyl-1-cyclohexene-1-carboxaldehyde | THE DOW CHEMICAL COMPANY (US) | 1990-05-22 | — | — | US | disclosed |
| US-4831137-A | Reaction products of pteridine and 4-isopropenyl-1-cyclohexene-1-carboxaldehyde | THE DOW CHEMICAL COMPANY (US) | 1989-05-16 | — | — | US | disclosed |
| US-4755600-A | Reaction products of pyrazine, pyridine, quinoline and quinoxaline derivatives and 4-isopropenyl-1-cyclohexene-1-carboxaldehyde | THE DOW CHEMICAL COMPANY (US) | 1988-07-05 | — | — | US | disclosed |
| US-4680347-A | Thermosettable polystyrylpyrazine polymers terminated with ethylenically unsaturated groups and cured products therefrom | THE DOW CHEMICAL COMPANY (US) | 1987-07-14 | — | — | US | disclosed |
| EP-0202244-A4 | CURED PRODUCTS FROM THERMOSETTABLE POLYMERS OR PREPOLYMERS PREPARED FROM POLYMETHYLATED PYRAZINES AND AROMATIC POLYALDEHYDES. | DOW CHEMICAL CO (US) | 1987-04-28 | — | — | EP | disclosed |
| US-4629770-A | Thermosettable polystyrylpyrazine polymers terminated with ethylenically unsaturated groups and cured products therefrom | THE DOW CHEMICAL COMPANY (US) | 1986-12-16 | — | — | US | disclosed |
| EP-0202244-A1 | CURED PRODUCTS FROM THERMOSETTABLE POLYMERS OR PREPOLYMERS PREPARED FROM POLYMETHYLATED PYRAZINES AND AROMATIC POLYALDEHYDES. | DOW CHEMICAL CO (US) | 1986-11-26 | — | — | EP | disclosed |
| WO-1986002932-A1 | THERMOSETTABLE POLYMERS OR PREPOLYMERS PREPARED FROM POLYMETHYLATED PYRAZINES AND AROMATIC POLYALDEHYDES AND CURED PRODUCTS THEREFROM | THE DOW CHEMICAL COMPANY (US) | 1986-05-22 | — | — | WO | disclosed |
| US-4543388-A | Thermosettable polymers or prepolymers prepared from polymethylated pyrazines and aromatic polyaldehydes and cured products therefrom | THE DOW CHEMICAL COMPANY (US) | 1985-09-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170029367-A1 | Substituted Aromatic Sulfur Compounds and Methods of Their Use | RB1, NRAS, TP53 | MEN1 3051/4885KMT2A 1938/4885PSMB5 1283/4885 |
| US-20160372675-A1 | MACROMOLECULAR COMPOUND | EXOSC4, TRPC6, MRPS22 | MEN1 2256/4885KMT2A 2742/4885PSMB5 259/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.