Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 6/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | NCK1 | P16333 | 1/20 | 0.39 |
| ▸ | BACE1 | P56817 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | PDE2A | O00408 | 1/20 | 0.37 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.37 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2514453 | 0.82 | TLR8 (0.56) | TLR8ACHE | |
| SCHEMBL18082993 | 0.79 | NQO2 (0.47) | TLR8TLR7KMT2AACHEKDM4E | |
| SCHEMBL18083009 | 0.79 | NQO2 (0.47) | TLR8TLR7KMT2AACHEKDM4E | |
| SCHEMBL18082979 | 0.76 | KDM4E (0.45) | TLR8TLR7KMT2AACHEKDM4E | |
| SCHEMBL18082992 | 0.76 | NQO2 (0.52) | TLR8CYP1A2TLR7KMT2AKDM4E | |
| SCHEMBL18082994 | 0.72 | KDM4E (0.47) | TLR8TLR7KMT2APSMB5KDM4E | |
| SCHEMBL30277428 | 0.70 | TLR8 (0.46) | TLR8KMT2AKDM4E | |
| SCHEMBL19260213 | 0.69 | TDP1 (0.52) | TLR8CYP1A2ACHEKDM4E | |
| SCHEMBL862359 | 0.69 | MEN1 (0.56) | CYP1A2NCK1BACE1PKMKMT2A | |
| SCHEMBL14137775 | 0.68 | GRM1 (0.48) | CYP1A2NCK1BACE1PKMKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1332133-B1 | METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS | JANSSEN PHARMACEUTICA NV (BE) | 2008-07-09 | — | — | EP | disclosed |