Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | COXFA4 | O00483 | 1/20 | 0.81 |
| ▸ | HIF1A | Q16665 | 17/20 | 0.55 |
| ▸ | EPAS1 | Q99814 | 14/20 | 0.55 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.53 |
| ▸ | EP300 | Q09472 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14098881 | 0.92 | COXFA4 (0.74) | COXFA4HIF1AEPAS1HSP90AA1EP300 | |
| SCHEMBL12315602 | 0.89 | COXFA4 (0.84) | COXFA4HIF1AEPAS1HSP90AA1EP300 | |
| SCHEMBL14139185 | 0.89 | COXFA4 (1.00) | COXFA4HIF1AEPAS1HSP90AA1 | |
| SCHEMBL14098877 | 0.86 | COXFA4 (0.89) | COXFA4HIF1AEPAS1HSP90AA1 | |
| SCHEMBL16694415 | 0.85 | HIF1A (0.66) | COXFA4HIF1AEPAS1HSP90AA1EP300 | |
| SCHEMBL16694306 | 0.82 | HIF1A (0.62) | COXFA4HIF1AEPAS1HSP90AA1 | |
| SCHEMBL16694172 | 0.82 | COXFA4 (0.59) | COXFA4HIF1AEPAS1HSP90AA1EP300 | |
| SCHEMBL12315469 | 0.82 | COXFA4 (0.66) | COXFA4HIF1AEPAS1EP300 | |
| SCHEMBL14139406 | 0.80 | KMT2A (0.59) | COXFA4HIF1AEPAS1HSP90AA1 | |
| SCHEMBL27665986 | 0.78 | COXFA4 (0.57) | COXFA4HIF1AEPAS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7410998-B2 | Inhibitors of NADH:ubiquinone oxidoreductase | THE SCRIPPS RESEARCH INSTITUTE (US) | 2008-08-12 | — | — | US | disclosed |