Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.59 |
| ▸ | COXFA4 | O00483 | 1/20 | 0.58 |
| ▸ | HIF1A | Q16665 | 10/20 | 0.51 |
| ▸ | EPAS1 | Q99814 | 5/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16694172 | 0.85 | COXFA4 (0.59) | COXFA4HIF1AEPAS1ALDH1A1GAA | |
| SCHEMBL14139261 | 0.80 | COXFA4 (0.81) | COXFA4HIF1AEPAS1HSP90AA1 | |
| SCHEMBL4492932 | 0.80 | ALDH1A1 (0.51) | KMT2ACOXFA4HIF1AEPAS1MEN1 | |
| SCHEMBL16694459 | 0.80 | HIF1A (0.64) | KMT2ACOXFA4HIF1AEPAS1MEN1 | |
| SCHEMBL11398330 | 0.79 | COXFA4 (0.62) | COXFA4HIF1AEPAS1MAPTSMN1; SMN2 | |
| SCHEMBL16694311 | 0.78 | ABCG2 (0.62) | KMT2AMEN1MAPT | |
| SCHEMBL16694310 | 0.78 | ABCG2 (0.62) | KMT2AMEN1MAPT | |
| SCHEMBL17933739 | 0.78 | MAPT (0.70) | KMT2AMEN1MAPTSMN1; SMN2KDM4E | |
| SCHEMBL16694415 | 0.77 | HIF1A (0.66) | COXFA4HIF1AEPAS1HSP90AA1 | |
| SCHEMBL16694474 | 0.77 | HIF1A (0.67) | KMT2ACOXFA4HIF1AEPAS1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7410998-B2 | Inhibitors of NADH:ubiquinone oxidoreductase | THE SCRIPPS RESEARCH INSTITUTE (US) | 2008-08-12 | — | — | US | disclosed |