Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 5/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | FLT3 | P36888 | 3/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 2/20 | 0.38 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4603577 | 0.87 | TGFBR1 (0.55) | MAPTNPC1RAB9ANPSR1LMNA | |
| SCHEMBL13184960 | 0.80 | MAPT (0.53) | MAPTNPSR1TP53LMNATDP1 | |
| SCHEMBL13166087 | 0.78 | L3MBTL1 (0.55) | MAPTNPSR1TP53LMNATDP1 | |
| SCHEMBL3355200 | 0.78 | L3MBTL1 (0.55) | MAPTNPSR1TP53LMNATDP1 | |
| SCHEMBL4606194 | 0.78 | TGFBR1 (0.58) | MAPTNPC1RAB9ANPSR1LMNA | |
| SCHEMBL4606456 | 0.75 | TGFBR1 (0.70) | MAPTNPC1RAB9ANPSR1LMNA | |
| SCHEMBL3565780 | 0.74 | MEN1 (0.59) | MAPTNPC1RAB9ANPSR1LMNA | |
| SCHEMBL4604198 | 0.74 | TGFBR1 (0.58) | MAPTNPC1RAB9ANPSR1LMNA | |
| SCHEMBL4604442 | 0.74 | TGFBR1 (0.58) | MAPTNPC1RAB9ALMNATGFBR1 | |
| SCHEMBL4603429 | 0.74 | MAPT (0.62) | MAPTTP53FLT3TGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1753512-B1 | TETRAHYDROPYRIDOTHIOPHENES | NYCOMED GMBH (DE) | 2008-07-09 | — | — | EP | disclosed |