Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 8/20 | 0.44 |
| ▸ | RXRB | P28702 | 8/20 | 0.44 |
| ▸ | RXRG | P48443 | 6/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | PKM | P14618 | 4/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.39 |
| ▸ | C5 | P01031 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18359190 | 0.82 | GAA (0.42) | RXRARXRBRXRGKDM4EHSD17B10 | |
| SCHEMBL8532973 | 0.79 | ALDH1A1 (0.45) | RXRARXRBRXRGALDH1A1KDM4E | |
| SCHEMBL4632525 | 0.71 | RXRA (0.54) | RXRARXRBRXRGALDH1A1KDM4E | |
| SCHEMBL6480225 | 0.71 | ALDH1A1 (0.56) | ALDH1A1KDM4ECYP2C19DDAH1CYP1A2 | |
| SCHEMBL1912604 | 0.71 | NPC1 (0.40) | ALDH1A1KDM4ECYP1A2SMN1; SMN2MAPT | |
| SCHEMBL8532736 | 0.70 | LMNA (0.49) | KDM4EPOLBHPGDTSHRLMNA | |
| SCHEMBL2040301 | 0.70 | — | — | |
| SCHEMBL20275214 | 0.69 | RXRA (0.45) | RXRARXRBRXRGKDM4ECYP2C19 | |
| SCHEMBL24082692 | 0.69 | PPARA (0.60) | ALDH1A1SMN1; SMN2POLBTDP1HPGD | |
| SCHEMBL13851669 | 0.69 | HDAC1 (0.40) | RXRARXRBRXRGSMN1; SMN2HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1939205-A1 | TRICYCLIC COMPOUND | Daiichi Sankyo Company, Limited (JP) | 2008-07-02 | — | — | EP | disclosed |