Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 3/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | BTK | Q06187 | 7/20 | 0.36 |
| ▸ | SRC | P12931 | 7/20 | 0.36 |
| ▸ | LYN | P07948 | 5/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | KIT | P10721 | 2/20 | 0.33 |
| ▸ | LCK | P06239 | 1/20 | 0.33 |
| ▸ | PGR | P06401 | 1/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.33 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.33 |
| ▸ | FLT1 | P17948 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12341853 | 0.91 | CSF1R (0.54) | CSF1RCYP1A2BTKSRCLYN | |
| SCHEMBL12341433 | 0.88 | CSF1R (0.53) | CSF1RCYP1A2CYP2C19BRD4CYP3A4 | |
| SCHEMBL12343934 | 0.78 | CSF1R (0.55) | CSF1RCYP1A2CYP2C19CYP3A4CYP2D6 | |
| SCHEMBL12338611 | 0.77 | CSF1R (0.40) | CSF1RCYP1A2CYP2C19BRD4KIT | |
| SCHEMBL21304793 | 0.76 | CSF1R (0.59) | CSF1RCYP1A2CYP2C19CYP3A4CYP2D6 | |
| SCHEMBL1267558 | 0.75 | CSF1R (0.75) | CSF1RCYP1A2CYP2C19BRD4CYP3A4 | |
| SCHEMBL14147163 | 0.75 | KDR (0.44) | CSF1RCYP1A2CYP2C19CYP3A4FLT1 | |
| SCHEMBL12342106 | 0.75 | CSF1R (0.51) | CSF1RCYP2C19BRD4KITLCK | |
| SCHEMBL12341431 | 0.75 | CSF1R (0.49) | CSF1RBRD4KITKDRFLT3 | |
| SCHEMBL19302326 | 0.72 | CSF1R (0.58) | CSF1RCYP1A2CYP2C19CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008079909-A1 | PYRROLO [2,3-B] PYRIDINES AS KINASE MODULATORS | PLEXXIKON, INC. (US) | 2008-07-03 | — | — | WO | disclosed |