Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.43 |
| ▸ | AOX1 | Q06278 | 1/20 | 0.43 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.41 |
| ▸ | TACR2 | P21452 | 1/20 | 0.40 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.40 |
| ▸ | USP28 | Q96RU2 | 1/20 | 0.40 |
| ▸ | USP25 | Q9UHP3 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | RXRA | P19793 | 1/20 | 0.39 |
| ▸ | RXRB | P28702 | 1/20 | 0.39 |
| ▸ | RXRG | P48443 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | TTR | P02766 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL856265 | 0.84 | ALDH1A1 (0.57) | KIF11ALDH1A1TACR2MEN1POLB | |
| SCHEMBL7255672 | 0.78 | ALDH1A1 (0.46) | ALDH1A1AOX1TACR2MRGPRX4RXRA | |
| SCHEMBL1414753 | 0.76 | ALDH1A1 (0.56) | ALDH1A1AOX1MEN1POLBKMT2A | |
| SCHEMBL2697346 | 0.76 | ESRRA (0.53) | ALDH1A1AOX1MEN1POLBKMT2A | |
| SCHEMBL14682676 | 0.75 | MAOA (0.57) | ALDH1A1AOX1TACR2MEN1KMT2A | |
| SCHEMBL24445838 | 0.75 | KDM4E (0.57) | KIF11ALDH1A1AOX1HPGDTTR | |
| SCHEMBL1180820 | 0.74 | MAOA (0.56) | ALDH1A1AOX1TACR2POLBKMT2A | |
| SCHEMBL48409 | 0.73 | KIF11 (0.73) | KIF11ALDH1A1SMN1; SMN2 | |
| SCHEMBL29438427 | 0.73 | KIF11 (0.73) | KIF11ALDH1A1SMN1; SMN2 | |
| SCHEMBL18002971 | 0.73 | IDO1 (0.50) | KIF11ALDH1A1TACR2MRGPRX4USP28 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008079909-A1 | PYRROLO [2,3-B] PYRIDINES AS KINASE MODULATORS | PLEXXIKON, INC. (US) | 2008-07-03 | — | — | WO | disclosed |