Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM2 | Q00987 | 8/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | CD74 | P04233 | 1/20 | 0.35 |
| ▸ | MIF | P14174 | 1/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.35 |
| ▸ | P4HB | P07237 | 1/20 | 0.35 |
| ▸ | MDM4 | O15151 | 1/20 | 0.35 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1414601 | 0.90 | KMT2A (0.46) | MDM2KMT2AMEN1POLBHSP90AA1 | |
| SCHEMBL1414861 | 0.90 | KMT2A (0.46) | MDM2KMT2AMEN1POLBHSP90AA1 | |
| SCHEMBL1414549 | 0.90 | KMT2A (0.46) | MDM2KMT2AMEN1POLBHSP90AA1 | |
| SCHEMBL836906 | 0.80 | MET (0.39) | MDM2P2RX7 | |
| SCHEMBL837795 | 0.74 | CNR2 (0.43) | MDM2 | |
| SCHEMBL837576 | 0.74 | NR3C1 (0.40) | MDM2P2RX7 | |
| SCHEMBL480059 | 0.73 | NT5E (0.38) | — | |
| SCHEMBL837462 | 0.72 | AR (0.35) | MDM2P2RX7 | |
| SCHEMBL836784 | 0.71 | PDE2A (0.39) | MDM2 | |
| SCHEMBL837634 | 0.71 | TRPV1 (0.38) | KMT2AMEN1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2205562-B1 | 1,1,1-TRIFLUORO-2-HYDROXY-3-PHENYLPROPANE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2011-03-16 | — | — | EP | claimed |