Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC7 | O00311 | 5/20 | 0.61 |
| ▸ | DBF4 | Q9UBU7 | 5/20 | 0.61 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.53 |
| ▸ | CDK2 | P24941 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.51 |
| ▸ | PPARG | P37231 | 1/20 | 0.51 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.51 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14148621 | 0.82 | ALDH1A1 (0.72) | CDC7DBF4CCNE1CDK2ALDH1A1 | |
| SCHEMBL975727 | 0.79 | CDC7 (0.86) | CDC7DBF4CCNE1CDK2ALDH1A1 | |
| SCHEMBL14148622 | 0.79 | CDC7 (0.59) | CDC7DBF4CCNE1CDK2ALDH1A1 | |
| SCHEMBL975863 | 0.76 | CDC7 (0.68) | CDC7DBF4CCNE1CDK2ALDH1A1 | |
| SCHEMBL16038025 | 0.76 | ALDH1A1 (0.60) | CDC7DBF4ALDH1A1KDM4ERXFP1 | |
| SCHEMBL978378 | 0.76 | CDC7 (1.00) | CDC7DBF4CCNE1CDK2ALDH1A1 | |
| SCHEMBL14148633 | 0.75 | CDC7 (0.56) | CDC7DBF4CCNE1CDK2ALDH1A1 | |
| SCHEMBL27920107 | 0.75 | KDM4E (0.67) | CDC7DBF4CCNE1CDK2ALDH1A1 | |
| SCHEMBL974859 | 0.75 | CDC7 (0.84) | CDC7DBF4CCNE1CDK2ALDH1A1 | |
| SCHEMBL14148658 | 0.74 | LMNA (0.76) | CDC7DBF4ALDH1A1KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008090382-A1 | THIAZOLE AND OXAZOLE DERIVATIVES FOR USE IN THE TREATMENT OF PRION DISEASES, CANCER AND CONDITIONS OF THE CENTRAL NERVOUS SYSTEM AS WELL AS IN THE REGULATION OF STEM CELLS | THE UNIVERSITY OF SHEFFIELD (GB) | 2008-07-31 | — | — | WO | disclosed |