Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.66 |
| ▸ | NOTUM | Q6P988 | 3/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | AHR | P35869 | 2/20 | 0.50 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.47 |
| ▸ | DPP4 | P27487 | 1/20 | 0.45 |
| ▸ | PTAFR | P25105 | 1/20 | 0.41 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.40 |
| ▸ | F12 | P00748 | 3/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.40 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.40 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | MMP9 | P14780 | 1/20 | 0.39 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2818152 | 0.85 | MAPK1 (0.63) | MAPK1NOTUMHPGDAHRHSD17B3 | |
| SCHEMBL30252940 | 0.84 | MAPK1 (0.62) | MAPK1NOTUMHPGDAHRHSD17B3 | |
| SCHEMBL11966963 | 0.84 | MAPK1 (0.58) | MAPK1NOTUMHPGDAHRHSD17B3 | |
| SCHEMBL19644152 | 0.83 | MAPK1 (0.61) | MAPK1NOTUMHPGDAHRDPP4 | |
| SCHEMBL19652058 | 0.83 | MAPK1 (0.69) | MAPK1NOTUMHPGDAHRDPP4 | |
| SCHEMBL7563761 | 0.80 | MAPK1 (0.45) | MAPK1NOTUMHPGDAHRDPP4 | |
| SCHEMBL537566 | 0.80 | MAPK1 (1.00) | MAPK1HPGDAHRNAMPTMAPT | |
| SCHEMBL6618480 | 0.79 | MAPK1 (0.56) | MAPK1NOTUMHPGDAHRDPP4 | |
| SCHEMBL11882123 | 0.77 | TMPRSS2 (0.58) | MAPK1NOTUMHPGDAHRDPP4 | |
| SCHEMBL19657579 | 0.77 | MAPK1 (0.54) | MAPK1NOTUMHPGDAHRHSD17B3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 69 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170340604-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2017-11-30 | — | — | US | disclosed |
| CN-101657411-B | Preparation methods of 4-acetyl-2,3,4,5-tetrahydro- benzo[1,4]diazepine and their intermediates | TOPHARMAN SHANGHAI CO LTD | 2013-04-10 | — | — | CN | disclosed |
| CN-101657411-B | Preparation methods of 4-acetyl-2,3,4,5-tetrahydro- benzo[1,4]diazepine and their intermediates | TOPHARMAN SHANGHAI CO LTD | 2013-04-10 | — | — | CN | disclosed |
| US-8242264-B2 | Process for preparing 4-acetyl-2,3,4,5-tetrahydro-benzo[1,4]diazepine and the intermediates thereof | TOPHARMAN SHANGHAI CO., LTD. (CN) | 2012-08-14 | — | — | US | disclosed |
| US-8242264-B2 | Process for preparing 4-acetyl-2,3,4,5-tetrahydro-benzo[1,4]diazepine and the intermediates thereof | TOPHARMAN SHANGHAI CO., LTD. (CN) | 2012-08-14 | — | — | US | disclosed |
| US-8242264-B2 | Process for preparing 4-acetyl-2,3,4,5-tetrahydro-benzo[1,4]diazepine and the intermediates thereof | TOPHARMAN SHANGHAI CO., LTD. (CN) | 2012-08-14 | — | — | US | disclosed |
| US-8242264-B2 | Process for preparing 4-acetyl-2,3,4,5-tetrahydro-benzo[1,4]diazepine and the intermediates thereof | TOPHARMAN SHANGHAI CO., LTD. (CN) | 2012-08-14 | — | — | US | disclosed |
| US-8242264-B2 | Process for preparing 4-acetyl-2,3,4,5-tetrahydro-benzo[1,4]diazepine and the intermediates thereof | TOPHARMAN SHANGHAI CO., LTD. (CN) | 2012-08-14 | — | — | US | disclosed |
| EP-2163538-B1 | PREPARATION METHODS OF 4-ACETYL-2,3,4,5-TETRAHYDRO- BENZO[1,4]DIAZEPINE AND THEIR INTERMEDIATES | TOPHARMAN SHANGHAI CO LTD (CN) | 2012-01-25 | — | — | EP | disclosed |
| EP-2163538-B1 | PREPARATION METHODS OF 4-ACETYL-2,3,4,5-TETRAHYDRO- BENZO[1,4]DIAZEPINE AND THEIR INTERMEDIATES | TOPHARMAN SHANGHAI CO LTD (CN) | 2012-01-25 | — | — | EP | disclosed |
| US-20040009970-A1 | [1,4]Diazepino[6,7,1-ij]quinoline derivatives as antipsychotic and antiobesity agents | WYETH | 2004-01-15 | — | — | US | disclosed |
| WO-2003091250-A1 | [1,4]DIAZEPINO[6,7,1-IJ]QUINOLINE DERIVATIVES AS ANTI PSYCHOTIC AND ANTIOBESITY AGENTS | WYETH (US) | 2003-11-06 | — | — | WO | disclosed |
| EP-1330457-A2 | CYCLOPENTA[B][1,4] DIAZEPINO[6,7,1-HI]INDOLES AS 5HT2C ANTAGONISTS | Wyeth (US) | 2003-07-30 | — | — | EP | disclosed |
| US-6503900-B2 | For treatment or prevention of disorders such as obsessive-compulsive disorder, depression, anxiety, schizophrenia | WYETH | 2003-01-07 | — | — | US | disclosed |
| US-20020119966-A1 | Cycloocta[b][1,4]diazepino[6,7,1-hi]indoles and derivatives | AMERICAN HOME PRODUCTS CORPORATION (US) | 2002-08-29 | — | — | US | disclosed |
| US-20020107242-A1 | Cyclopenta[b][1,4]diazepino[6,7,1-hi]indoles and derivatives | AMERICAN HOME PRODUCTS CORPORATION | 2002-08-08 | — | — | US | disclosed |
| US-20020086860-A1 | [1,4]Diazepino [6,7,1-jk] carbazoles and derivatives | AMERICAN HOME PRODUCTS CORPORATION | 2002-07-04 | — | — | US | disclosed |
| WO-2002042304-A2 | CYCLOPENTA[B][1,4] DIAZEPINO[6,7,1-HI]INDOLES AS 5HT2C ANTAGONISTS | WYETH (US) | 2002-05-30 | — | — | WO | disclosed |
| US-20020062022-A1 | Processes for preparation of cyclopenta [b] [1,4] diazepino [6,7,1-hi] indoles and derivatives | AMERICAN HOME PRODUCTS CORPORATION (US) | 2002-05-23 | — | — | US | disclosed |
| WO-2002036596-A2 | CYCLOALKYL[b][1,4]DIAZEPINO[6,7,1-hi]INDOLES AND DERIVATIVES | WYETH (US) | 2002-05-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020086860-A1 | [1,4]Diazepino [6,7,1-jk] carbazoles and derivatives | GRIK1, GRIK3, GRIK4 | MAPK1 2104/4885NOTUM 3098/4885HPGD 4023/4885 |
| US-20020107242-A1 | Cyclopenta[b][1,4]diazepino[6,7,1-hi]indoles and derivatives | CNR1, HCRTR1, HTR3C | MAPK1 2454/4885NOTUM 3260/4885HPGD 3338/4885 |
| US-20020119966-A1 | Cycloocta[b][1,4]diazepino[6,7,1-hi]indoles and derivatives | HTR1A, HCRTR2, HTR3B | MAPK1 1832/4885NOTUM 3843/4885HPGD 3535/4885 |
| US-20020062022-A1 | Processes for preparation of cyclopenta [b] [1,4] diazepino [6,7,1-hi] indoles and derivatives | AHR, HTR1A, IDO1 | MAPK1 565/4885NOTUM 4153/4885HPGD 2977/4885 |
| US-20040009970-A1 | [1,4]Diazepino[6,7,1-ij]quinoline derivatives as antipsychotic and antiobesity agents | HTR2C, HTR1A, HTR1D | MAPK1 744/4885NOTUM 3531/4885HPGD 3428/4885 |
| US-20170340604-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | BRD4, BRDT, BRD3 | MAPK1 662/4885NOTUM 2215/4885HPGD 1204/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.