Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 13/20 | 0.46 |
| ▸ | CA1 | P00915 | 12/20 | 0.46 |
| ▸ | CA9 | Q16790 | 9/20 | 0.46 |
| ▸ | CA3 | P07451 | 1/20 | 0.46 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.45 |
| ▸ | PNMT | P11086 | 1/20 | 0.45 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.45 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.45 |
| ▸ | CA12 | O43570 | 4/20 | 0.44 |
| ▸ | CA7 | P43166 | 6/20 | 0.40 |
| ▸ | CA14 | Q9ULX7 | 6/20 | 0.40 |
| ▸ | CA4 | P22748 | 1/20 | 0.38 |
| ▸ | CA6 | P23280 | 1/20 | 0.38 |
| ▸ | CA5A | P35218 | 1/20 | 0.38 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.38 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.34 |
| ▸ | PHLPP1 | O60346 | 1/20 | 0.34 |
| ▸ | AKT1 | P31749 | 1/20 | 0.34 |
| ▸ | ILK | Q13418 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14058835 | 0.79 | ADRA2A (0.39) | CA2CA1CA9CA3ADRA2A | |
| SCHEMBL31647361 | 0.77 | SIRT2 (0.40) | PNMTALDH1A1MAPT | |
| SCHEMBL14058834 | 0.77 | SMN1; SMN2 (0.56) | PNMTALDH1A1 | |
| SCHEMBL31646603 | 0.77 | GFER (0.32) | ADRA2APNMTADRA2BADRA2C | |
| SCHEMBL30288495 | 0.76 | CA2 (0.51) | CA2CA1CA9CA3ADRA2A | |
| SCHEMBL4870530 | 0.74 | PARP10 (0.43) | PNMTALDH1A1MAPTPARP10PARP11 | |
| SCHEMBL7218785 | 0.71 | ACHE (0.48) | CA2CA1CA9CA7CA14 | |
| Hydrochloric Acid SCHEMBL4866638 | 0.70 | ACHE (0.47) | CA2CA1CA9CA7CA14 | |
| SCHEMBL29710882 | 0.70 | CA1 (0.81) | CA2CA1CA9ADRA2APNMT | |
| SCHEMBL3238863 | 0.70 | CA1 (0.81) | CA2CA1CA9ADRA2APNMT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2714681-B1 | SUBSTITUTED SULFONAMIDES USEFUL AS ANTIAPOPTOTIC BCL INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2015-06-24 | — | — | EP | disclosed |
| WO-2012162365-A1 | SUBSTITUTED SULFONAMIDES USEFUL AS ANTIAPOPTOTIC BCL INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-11-29 | — | — | WO | disclosed |