Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 10/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.43 |
| ▸ | MEN1 | O00255 | 7/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | RECQL | P46063 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | MPO | P05164 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4551595 | 0.78 | KMT2A (0.56) | ALDH1A1POLBMAPTKMT2AMEN1 | |
| SCHEMBL8366653 | 0.72 | CYP1A2 (0.54) | ALDH1A1POLBMAPTKMT2AMEN1 | |
| SCHEMBL14959209 | 0.72 | KMT2A (0.65) | ALDH1A1POLBMAPTKMT2AMEN1 | |
| SCHEMBL1415008 | 0.70 | ALDH1A1 (0.57) | ALDH1A1POLBMAPTKMT2AMEN1 | |
| SCHEMBL4597359 | 0.70 | ALDH1A1 (0.53) | ALDH1A1POLBMAPTKMT2AMEN1 | |
| SCHEMBL30707844 | 0.69 | PIN1 (0.55) | ALDH1A1MAPTKMT2AMEN1CYP1A2 | |
| SCHEMBL4675197 | 0.69 | POLB (0.51) | ALDH1A1POLBMAPTKMT2AMEN1 | |
| SCHEMBL8077743 | 0.69 | MAPT (0.41) | ALDH1A1POLBMAPTKMT2AMEN1 | |
| SCHEMBL10844608 | 0.68 | AR (0.44) | ALDH1A1POLBMAPTKMT2AMEN1 | |
| SCHEMBL26241758 | 0.68 | PIN1 (0.57) | ALDH1A1MAPTKMT2AMEN1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150202195-A1 | SMALL MOLECULE INHIBITORS FOR THE TREATMENT OR PREVENTION OF DENGUE VIRUS INFECTION | SIGA TECHNOLOGIES, INC. | 2015-07-23 | — | — | US | claimed |
| US-9029376-B2 | Small molecule inhibitors for the treatment or prevention of dengue virus infection | SIGA TECHNOLOGIES, INC. (US) | 2015-05-12 | — | — | US | claimed |
| EP-2293671-A1 | SMALL MOLECULE INHIBITORS FOR THE TREATMENT OR PREVENTION OF DENGUE VIRUS INFECTION | Siga Technologies, Inc. (US) | 2011-03-16 | — | — | EP | claimed |
| US-9029376-B2 | Small molecule inhibitors for the treatment or prevention of dengue virus infection | SIGA TECHNOLOGIES, INC. (US) | 2015-05-12 | — | — | US | disclosed |
| US-20110158940-A1 | SAMLL MOLECULE INHIBITORS FOR THE TREATMENT OR PREVENTION OF DENGUE VIRUS INFECTION | SIGA TECHNOLOGIES, INC. | 2011-06-30 | — | — | US | disclosed |
| EP-2293671-A1 | SMALL MOLECULE INHIBITORS FOR THE TREATMENT OR PREVENTION OF DENGUE VIRUS INFECTION | Siga Technologies, Inc. (US) | 2011-03-16 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150202195-A1 | SMALL MOLECULE INHIBITORS FOR THE TREATMENT OR PREVENTION OF DENGUE VIRUS INFECTION | SNRPE, EIF2AK2, HAVCR2 | ALDH1A1 3106/4885POLB 3721/4885MAPT 219/4885 |
| US-20110158940-A1 | SAMLL MOLECULE INHIBITORS FOR THE TREATMENT OR PREVENTION OF DENGUE VIRUS INFECTION | HAVCR2, HNRNPLL, SAMSN1 | ALDH1A1 2694/4885POLB 4523/4885MAPT 480/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.