Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 7/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.56 |
| ▸ | NPC1 | O15118 | 4/20 | 0.56 |
| ▸ | RAB9A | P51151 | 4/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 10/20 | 0.55 |
| ▸ | GAA | P10253 | 2/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.55 |
| ▸ | MEN1 | O00255 | 6/20 | 0.55 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.54 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.54 |
| ▸ | RECQL | P46063 | 3/20 | 0.53 |
| ▸ | HTT | P42858 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14959209 | 0.89 | KMT2A (0.65) | KMT2ASMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL1415008 | 0.83 | ALDH1A1 (0.57) | KMT2ASMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL13381572 | 0.82 | NPC1 (0.61) | SMN1; SMN2NPC1RAB9ACYP1A2CYP3A4 | |
| SCHEMBL4675197 | 0.82 | POLB (0.51) | KMT2ASMN1; SMN2NPC1RAB9ATP53 | |
| SCHEMBL8366653 | 0.80 | CYP1A2 (0.54) | KMT2ASMN1; SMN2NPC1RAB9ACYP1A2 | |
| SCHEMBL8251328 | 0.79 | KMT2A (0.77) | KMT2ASMN1; SMN2NPC1RAB9ACYP1A2 | |
| SCHEMBL14311148 | 0.78 | LMNA (0.57) | KMT2ASMN1; SMN2NPC1RAB9ACYP1A2 | |
| SCHEMBL1415007 | 0.78 | ALDH1A1 (0.44) | KMT2ASMN1; SMN2NPC1RAB9ATP53 | |
| SCHEMBL17712421 | 0.77 | MAPT (0.69) | KMT2ASMN1; SMN2NPC1RAB9ATP53 | |
| SCHEMBL7745159 | 0.77 | RAB9A (0.66) | KMT2ASMN1; SMN2NPC1RAB9ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009149054-A1 | SMALL MOLECULE INHIBITORS FOR THE TREATMENT OR PREVENTION OF DENGUE VIRUS INFECTION | SIGA TECHNOLOGIES, INC. (US) | 2009-12-10 | — | — | WO | claimed |
| WO-2009149054-A1 | SMALL MOLECULE INHIBITORS FOR THE TREATMENT OR PREVENTION OF DENGUE VIRUS INFECTION | SIGA TECHNOLOGIES, INC. (US) | 2009-12-10 | — | — | WO | disclosed |