Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Piperazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLRA1 | P23415 | 1/20 | 0.62 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.62 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.62 |
| ▸ | GABRR1 | P24046 | 5/20 | 0.39 |
| ▸ | GABRA5 | P31644 | 4/20 | 0.38 |
| ▸ | GABRB2 | P47870 | 4/20 | 0.38 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.38 |
| ▸ | GABRA4 | P48169 | 3/20 | 0.38 |
| ▸ | GABRP | O00591 | 2/20 | 0.38 |
| ▸ | GABRD | O14764 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.38 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.38 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.38 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.38 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.38 |
| ▸ | GABRE | P78334 | 2/20 | 0.38 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.38 |
| ▸ | GABRG1 | Q8N1C3 | 2/20 | 0.38 |
| ▸ | GABRG3 | Q99928 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Glycine SCHEMBL11469989 | 0.94 | — | — | |
| Pyrrolidine SCHEMBL29129720 | 0.88 | GLRA1 (0.56) | GLRA1SLC6A9OR51E2GABRR1GABRA5 | |
| Glycine SCHEMBL3897442 | 0.88 | — | — | |
| Piperidine SCHEMBL1820163 | 0.86 | GLRA1 (0.53) | GLRA1SLC6A9OR51E2GABRR1GABRA5 | |
| Glycine SCHEMBL4884601 | 0.83 | — | — | |
| Glycine SCHEMBL2916898 | 0.83 | — | — | |
| Glycine SCHEMBL19100314 | 0.83 | GLRA1 (0.91) | GLRA1SLC6A9OR51E2GABRR1GABRA5 | |
| Morpholine SCHEMBL28216143 | 0.82 | KDM4E (0.50) | GLRA1SLC6A9OR51E2GABRR1GABRA5 | |
| Glycine SCHEMBL3863155 | 0.79 | — | — | |
| Glycine SCHEMBL5163283 | 0.79 | GLRA1 (0.83) | GLRA1SLC6A9OR51E2GABRR1GABRA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 72 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12569802-B2 | Guanidine-containing membranes and methods of using thereof | OHIO STATE INNOVATION FOUNDATION (US) | 2026-03-10 | — | — | US | claimed |
| US-20250312749-A1 | POLYAMIDINE-CONTAINING MEMBRANES FOR CO2 SEPARATIONS FROM GASEOUS STREAMS | UNITED STATES DEPARTMENT OF ENERGY | 2025-10-09 | — | — | US | claimed |
| EP-4587176-A2 | POLYGUANIDINE-CONTAINING MEMBRANES AND METHODS OF USING THEREOF | Ohio State Innovation Foundation (US) | 2025-07-23 | — | — | EP | claimed |
| WO-2025064987-A1 | POLYMERIC SUBSTRATES AND METHODS OF MAKING AND USING THEREOF | OHIO STATE INNOVATION FOUNDATION (US) | 2025-03-27 | — | — | WO | claimed |
| EP-4514512-A1 | POLYAMIDINE-CONTAINING MEMBRANES FOR CO2 SEPARATIONS FROM GASEOUS STREAMS | Ohio State Innovation Foundation (US) | 2025-03-05 | — | — | EP | claimed |
| US-12172136-B2 | Gas permeable membranes and methods of using thereof | OHIO STATE INNOVATION FOUNDATION (US) | 2024-12-24 | — | — | US | claimed |
| WO-2024238622-A2 | MEMBRANE-ADSORPTION PROCESS FOR DIRECT AIR CAPTURE | OHIO STATE INNOVATION FOUNDATION (US) | 2024-11-21 | — | — | WO | claimed |
| US-12023633-B2 | Membranes for gas separation | OHIO STATE INNOVATION FOUNDATION (US) | 2024-07-02 | — | — | US | claimed |
| WO-2024059033-A2 | POLYGUANIDINE-CONTAINING MEMBRANES AND METHODS OF USING THEREOF | OHIO STATE INNOVATION FOUNDATION (US) | 2024-03-21 | — | — | WO | claimed |
| US-20240082793-A1 | MEMBRANES FOR GAS SEPARATION | UNITED STATES DEPARTMENT OF ENERGY | 2024-03-14 | — | — | US | claimed |
| WO-2021236221-A1 | HIGH-PERFORMANCE COMPOSITE MEMBRANES FOR GAS SEPARATION | OHIO STATE INNOVATION FOUNDATION (US) | 2021-11-25 | — | — | WO | claimed |
| WO-2021236220-A1 | CROSSLINKED FACILITATED TRANSPORT MEMBRANE FOR HYDROGEN PURIFICATION FROM COAL-DERIVED SYNGAS | OHIO STATE INNOVATION FOUNDATION (US) | 2021-11-25 | — | — | WO | claimed |
| EP-3849689-A1 | MEMBRANES FOR GAS SEPARATION | Ohio State Innovation Foundation (US) | 2021-07-21 | — | — | EP | claimed |
| CN-112969520-A | Membrane for gas separation | 俄亥俄州创新基金会 | 2021-06-15 | — | — | CN | claimed |
| WO-2021041581-A1 | CO 2 UTILIZATION FOR CO PRODUCTION VIA FUEL CELL ENABLED BY CO 2-SELECTIVE MEMBRANE | OHIO STATE INNOVATION FOUNDATION (US) | 2021-03-04 | — | — | WO | claimed |
| US-20200398229-A1 | MEMBRANES FOR GAS SEPARATION | OHIO STATE INNOVATION FOUNDATION (US) | 2020-12-24 | — | — | US | claimed |
| WO-2020240522-A1 | GUANIDINE-CONTAINING MEMBRANES AND METHODS OF USING THEREOF | OHIO STATE INNOVATION FOUNDATION (US) | 2020-12-03 | — | — | WO | claimed |
| EP-3672708-A1 | MEMBRANES FOR GAS SEPARATION | Ohio State Innovation Foundation (US) | 2020-07-01 | — | — | EP | claimed |
| CN-111225729-A | Membrane for gas separation | 俄亥俄州创新基金会 | 2020-06-02 | — | — | CN | claimed |
| WO-2020056414-A1 | MEMBRANES FOR GAS SEPARATION | OHIO STATE INNOVATION FOUNDATION (US) | 2020-03-19 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12569802-B2 | Guanidine-containing membranes and methods of using thereof | GJA1, RNMT, GJB2 | GLRA1 49/4885SLC6A9 90/4885OR51E2 2424/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.