Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | UBE2M | P61081 | 3/20 | 0.46 |
| ▸ | DCUN1D1 | Q96GG9 | 3/20 | 0.46 |
| ▸ | ALOX5AP | P20292 | 4/20 | 0.45 |
| ▸ | FEN1 | P39748 | 4/20 | 0.45 |
| ▸ | ERN1 | O75460 | 2/20 | 0.43 |
| ▸ | ACLY | P53396 | 1/20 | 0.41 |
| ▸ | APP | P05067 | 1/20 | 0.41 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | MGLL | Q99685 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL312014 | 0.79 | DCK (0.59) | UBE2MDCUN1D1 | |
| SCHEMBL9867716 | 0.73 | MEN1 (0.67) | UBE2MDCUN1D1L3MBTL1MEN1KMT2A | |
| SCHEMBL14163236 | 0.71 | PARP1 (0.48) | PARP1MEN1KMT2AMGLL | |
| SCHEMBL8160992 | 0.65 | HSD11B1 (0.54) | ERN1MEN1KMT2AMGLL | |
| SCHEMBL19888021 | 0.65 | FASN (0.65) | — | |
| SCHEMBL27159530 | 0.64 | APP (0.81) | ERN1APPMGLL | |
| SCHEMBL32677328 | 0.64 | APP (0.81) | ERN1APPMGLL | |
| SCHEMBL8171370 | 0.64 | GRM5 (0.57) | ALOX5APFEN1L3MBTL1MEN1KMT2A | |
| SCHEMBL13243065 | 0.64 | ALOX5AP (0.48) | ALOX5APFEN1PARP1MEN1KMT2A | |
| SCHEMBL13243061 | 0.64 | ALOX5AP (0.48) | ALOX5APFEN1PARP1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008076779-A2 | 2-(PIPERIDIN-4-YL0XY)PYRIMIDIN-4-AMINE DERIVATIVES AS DEOXYCYTIDINE KINASE INHIBITORS FOR THE TREATMENT OF CANCER | LEXICON PHARMACEUTICALS, INC. (US) | 2008-06-26 | — | — | WO | disclosed |