Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.63 |
| ▸ | GAA | P10253 | 3/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.63 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.63 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.63 |
| ▸ | HTR6 | P50406 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | HTT | P42858 | 2/20 | 0.53 |
| ▸ | CRHBP | P24387 | 1/20 | 0.53 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.48 |
| ▸ | PTPRF | P10586 | 1/20 | 0.48 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.48 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1663322 | 0.83 | HTR6 (0.63) | MAPTHTR6MEN1KMT2AHTT | |
| SCHEMBL2033918 | 0.82 | KDM4E (0.53) | MAPTGAAALDH1A1L3MBTL1KDM4E | |
| SCHEMBL20718866 | 0.81 | ALDH1A1 (0.56) | MAPTGAAALDH1A1L3MBTL1KDM4E | |
| SCHEMBL9537129 | 0.80 | MAPT (0.60) | MAPTGAAALDH1A1L3MBTL1KDM4E | |
| SCHEMBL5309365 | 0.79 | HIF1A (0.63) | MAPTGAAALDH1A1L3MBTL1KDM4E | |
| SCHEMBL23579266 | 0.79 | HTR6 (0.59) | MAPTGAAHTR6MEN1KMT2A | |
| SCHEMBL18702632 | 0.79 | MEN1 (0.67) | MAPTALDH1A1MAPK1HTR6MEN1 | |
| SCHEMBL2036624 | 0.78 | KDM4E (0.55) | MAPTALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL10654179 | 0.78 | MAPT (0.55) | MAPTGAAALDH1A1L3MBTL1KDM4E | |
| SCHEMBL4535542 | 0.78 | ALDH1A1 (0.52) | MAPTGAAALDH1A1L3MBTL1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2718278-A1 | COMPOUNDS AS PPAR BETA/DELTA INHIBITORS FOR TREATING PPAR BETA/DELTA-MEDIATED DISEASES | Philipps-Universität Marburg (DE) | 2014-04-16 | — | — | EP | disclosed |
| WO-2012168345-A1 | COMPOUNDS AS PPAR BETA/DELTA INHIBITORS FOR TREATING PPAR BETA/DELTA-MEDIATED DISEASES | PHILIPPS-UNIVERSITÄT MARBURG (DE) | 2012-12-13 | — | — | WO | disclosed |
| WO-2012168345-A1 | COMPOUNDS AS PPAR BETA/DELTA INHIBITORS FOR TREATING PPAR BETA/DELTA-MEDIATED DISEASES | PHILIPPS-UNIVERSITÄT MARBURG (DE) | 2012-12-13 | — | — | WO | disclosed |