Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.60 |
| ▸ | MEN1 | O00255 | 5/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.60 |
| ▸ | CRHBP | P24387 | 3/20 | 0.60 |
| ▸ | CRHR2 | Q13324 | 3/20 | 0.60 |
| ▸ | GAA | P10253 | 2/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.60 |
| ▸ | HTT | P42858 | 1/20 | 0.60 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.60 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | HTR6 | P50406 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9538742 | 0.90 | MAPT (0.59) | MAPTMEN1KMT2AL3MBTL1CRHBP | |
| SCHEMBL6816524 | 0.90 | MAPT (0.59) | MAPTMEN1KMT2AL3MBTL1CRHBP | |
| SCHEMBL25258715 | 0.86 | MAPT (0.52) | MAPTMEN1KMT2AL3MBTL1CRHBP | |
| SCHEMBL10552169 | 0.86 | HTR6 (0.54) | MAPTMEN1KMT2AL3MBTL1CRHBP | |
| SCHEMBL2698732 | 0.86 | MAPT (0.58) | MAPTMEN1KMT2AL3MBTL1CRHBP | |
| SCHEMBL6474847 | 0.82 | HTR6 (0.58) | MAPTMEN1KMT2AL3MBTL1CRHBP | |
| SCHEMBL2130528 | 0.82 | MAPT (0.60) | MAPTMEN1KMT2AL3MBTL1CRHBP | |
| SCHEMBL14166196 | 0.80 | MAPT (0.63) | MAPTMEN1KMT2AL3MBTL1CRHBP | |
| SCHEMBL3449782 | 0.79 | LMNA (0.51) | MAPTL3MBTL1GAAHTTALDH1A1 | |
| SCHEMBL9537223 | 0.79 | MAPT (0.58) | MAPTMEN1KMT2AL3MBTL1CRHBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0151826-B1 | 4-[(Bicyclic heterocyclyl)-methyl and -hetero]-piperidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-03-31 | — | — | EP | disclosed |