SCHEMBL14175488

SCHEMBL14175488

O=C1CCC(C(F)(F)C(F)(F)C2CCC3(CC2)OCCO3)CC1

nearest known ligand 0.30

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.30
KMT2A Q03164 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14175487 0.93
SCHEMBL13766340 0.84
SCHEMBL13766339 0.79 TRIM24 (0.33) ALDH1A1
SCHEMBL14175486 0.77 LMNA (0.30)
SCHEMBL422994 0.76 ALDH1A1 (0.33) ALDH1A1KMT2A
SCHEMBL8517346 0.75 GPR119 (0.38) ALDH1A1KMT2A
SCHEMBL19339358 0.74 ALDH1A1 (0.33) ALDH1A1KMT2A
SCHEMBL14129084 0.72 GPR119 (0.41) ALDH1A1KMT2A
SCHEMBL742157 0.71 GPR119 (0.33) ALDH1A1KMT2A
SCHEMBL19884668 0.70 ALDH1A1 (0.33) ALDH1A1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7385067-B2 Process for the preparation of compounds having a CF2O bridge MERCK PATENT GMBH (DE) 2008-06-10 US disclosed
US-7385067-B2 Process for the preparation of compounds having a CF2O bridge MERCK PATENT GMBH (DE) 2008-06-10 US disclosed