Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAX8 | Q06710 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 2/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | TTK | P33981 | 1/20 | 0.34 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.34 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.34 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.34 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.34 |
| ▸ | HTR2C | P28335 | 2/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.34 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.33 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.33 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.33 |
| ▸ | CKS1B | P61024 | 1/20 | 0.33 |
| ▸ | SKP1 | P63208 | 1/20 | 0.33 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.33 |
| ▸ | NCEH1 | Q6PIU2 | 1/20 | 0.33 |
| ▸ | GBA1 | P04062 | 1/20 | 0.32 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.32 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23131099 | 0.89 | PAX8 (0.40) | PAX8BRD4TTKHTR2CSLC6A4 | |
| SCHEMBL14270683 | 0.87 | PAX8 (0.39) | PAX8BRD4TTKHTR2CSLC6A4 | |
| SCHEMBL20388075 | 0.87 | SYK (0.36) | PAX8PARP1CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL852583 | 0.86 | PAX8 (0.39) | PAX8BRD4TTKHTR2CSLC6A4 | |
| SCHEMBL4638852 | 0.86 | PAX8 (0.39) | PAX8BRD4HTR2CSLC6A4CREBBP | |
| SCHEMBL12705243 | 0.85 | ACHE (0.39) | PAX8BRD4TTKHTR2CSLC6A4 | |
| SCHEMBL852663 | 0.84 | KMT2A (0.42) | PAX8CYP1A2CYP2C19 | |
| SCHEMBL8038094 | 0.84 | PAX8 (0.37) | PAX8BRD4TTKHTR2CSLC6A4 | |
| SCHEMBL4919601 | 0.84 | PAX8 (0.37) | PAX8BRD4TTKHTR2CSLC6A4 | |
| SCHEMBL31128424 | 0.83 | CYP4F2 (0.39) | PAX8BRD4HTR2CSLC6A4CREBBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7368566-B2 | Process and intermediates for preparing benzazepines | SMITHKLINE BEECHAM CORPORATION (US) | 2008-05-06 | — | — | US | disclosed |