Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAX8 | Q06710 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 2/20 | 0.33 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 2/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | NQO2 | P16083 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.31 |
| ▸ | TTK | P33981 | 1/20 | 0.31 |
| ▸ | CKS1B | P61024 | 1/20 | 0.31 |
| ▸ | SKP1 | P63208 | 1/20 | 0.31 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.31 |
| ▸ | GBA1 | P04062 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL852583 | 0.84 | PAX8 (0.39) | PAX8BRD4IRAK4HTR2CSLC6A4 | |
| SCHEMBL23131099 | 0.84 | PAX8 (0.40) | PAX8BRD4IRAK4HTR2CSLC6A4 | |
| SCHEMBL14182011 | 0.84 | PAX8 (0.40) | PAX8CYP1A2CYP2C19BRD4IRAK4 | |
| SCHEMBL12705243 | 0.83 | ACHE (0.39) | PAX8BRD4IRAK4HTR2CSLC6A4 | |
| SCHEMBL14270683 | 0.83 | PAX8 (0.39) | PAX8CYP1A2CYP2C19BRD4IRAK4 | |
| SCHEMBL4638852 | 0.82 | PAX8 (0.39) | PAX8ALDH1A1BRD4HTR2CSLC6A4 | |
| SCHEMBL14270690 | 0.81 | CYP4F2 (0.39) | PAX8BRD4IRAK4HTR2CSLC6A4 | |
| SCHEMBL31128424 | 0.81 | CYP4F2 (0.39) | PAX8BRD4IRAK4HTR2CSLC6A4 | |
| SCHEMBL852663 | 0.80 | KMT2A (0.42) | PAX8ALDH1A1CYP1A2CYP2C19NPSR1 | |
| SCHEMBL22493865 | 0.80 | PAX8 (0.36) | PAX8BRD4IRAK4NPSR1NQO2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080045521-A1 | PHENYLALANINE DERIVATIVES | ASTRAZENECA AB (SE) | 2008-02-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080045521-A1 | PHENYLALANINE DERIVATIVES | ITGB5, ITGB1, ITGA2B | PAX8 4677/4885ALDH1A1 1037/4885CYP1A2 3894/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.